Degeneration and proliferation of astrocytes in the mouse dentate gyrus after pilocarpine-induced status epilepticus

Astrocytes are relatively resistant to injury compared to neurons and oligodendrocytes. Here, we report transient region-specific loss of astrocytes in mice early after pilocarpine-induced status epilepticus (SE). In the dentate hilus, immunoreactivity for glial acidic fibrillary protein (GFAP) was...

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Veröffentlicht in:	Experimental neurology 2006-10, Vol.201 (2), p.416-427
Hauptverfasser:	Borges, Karin, McDermott, Dayna, Irier, Hasan, Smith, Yoland, Dingledine, Raymond
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult progenitor cell Animals Astrocytes - chemistry Astrocytes - cytology Astrocytes - physiology Cell Count Cell Proliferation Dentate Gyrus - pathology Dentate Gyrus - physiopathology Dentate Gyrus - ultrastructure Glial fibrillary acidic protein Glial Fibrillary Acidic Protein - analysis Hilus Immunohistochemistry Kainate Mice Mice, Inbred Strains Microglia - cytology Microglia - physiology Microscopy, Confocal Microscopy, Electron Mouse strain Nerve Degeneration - pathology Nerve Degeneration - physiopathology Neurons - cytology Neurons - physiology Pilocarpine Rats Rats, Sprague-Dawley Seizure Species Specificity Status Epilepticus - chemically induced Status Epilepticus - physiopathology Stem cell Time Factors
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