Hematological and Biochemical Markers of Iron Status in a Male, Young, Physically Active Population
The aim of this study was to establish reference intervals (RIs) for the hemogram and iron status biomarkers in a physically active population. The study population included male volunteers (n=150) with an average age of 19 ± 1 years who had participated in a regular and controlled exercise program...
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| Veröffentlicht in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-7 |
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| description | The aim of this study was to establish reference intervals (RIs) for the hemogram and iron status biomarkers in a physically active population. The study population included male volunteers (n=150) with an average age of 19 ± 1 years who had participated in a regular and controlled exercise program for four months. Blood samples were collected to determine hematological parameters using a Sysmex XE-5000 analyzer (Sysmex, Kobe, Japan). Iron, total iron-binding capacity (TIBC), transferrin saturation and ferritin, and high-sensitivity C-reactive protein (CRP) concentrations in serum samples were measured using commercial kits (Roche Diagnostics, GmbH, Mannheim, Germany) and a Roche/Hitachi 902 analyzer. The RIs were established using the RefVal program 4.1b. The leucocyte count, TIBC, and CRP and ferritin concentrations exhibited higher RIs compared with those in a nonphysically active population. Thirty volunteers (outliers) were removed from the reference population due to blood abnormalities. Among the outliers, 46% exhibited higher CRP concentrations and lower concentrations of iron and reticulocyte hemoglobin compared with the nonphysically active population (P |
| doi_str_mv | 10.1155/2014/349182 |
| format | Article |
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The study population included male volunteers (n=150) with an average age of 19 ± 1 years who had participated in a regular and controlled exercise program for four months. Blood samples were collected to determine hematological parameters using a Sysmex XE-5000 analyzer (Sysmex, Kobe, Japan). Iron, total iron-binding capacity (TIBC), transferrin saturation and ferritin, and high-sensitivity C-reactive protein (CRP) concentrations in serum samples were measured using commercial kits (Roche Diagnostics, GmbH, Mannheim, Germany) and a Roche/Hitachi 902 analyzer. The RIs were established using the RefVal program 4.1b. The leucocyte count, TIBC, and CRP and ferritin concentrations exhibited higher RIs compared with those in a nonphysically active population. Thirty volunteers (outliers) were removed from the reference population due to blood abnormalities. Among the outliers, 46% exhibited higher CRP concentrations and lower concentrations of iron and reticulocyte hemoglobin compared with the nonphysically active population (P<0.001). Our results showed that it is important to establish RIs for certain laboratory parameters in a physically active population, especially for tests related to the inflammatory response and iron metabolism.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/349182</identifier><identifier>PMID: 25045665</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Adult ; Athletes ; Biological markers ; Biomarkers ; Biomarkers - blood ; C-Reactive Protein - metabolism ; Chronic illnesses ; Colleges & universities ; Exercise ; Ferritins - blood ; Health aspects ; Hematologic Tests ; Hematology ; Humans ; Identification and classification ; Immune system ; Iron ; Iron - metabolism ; Iron in the body ; Japan ; Leukocyte Count ; Male ; Physical fitness ; Proteins ; Reference Values ; Reference values (Medicine) ; Sickle cell disease ; Transferrins - blood ; Young men</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-7</ispartof><rights>Copyright © 2014 Lázaro Alessandro Soares Nunes et al.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 Lázaro Alessandro Soares Nunes et al. Lázaro Alessandro Soares Nunes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Lázaro Alessandro Soares Nunes et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-80d962135bfcd2012bdf8d294af9e6a2be711a70d7a1c4f34654fc285005c6a83</citedby><cites>FETCH-LOGICAL-c527t-80d962135bfcd2012bdf8d294af9e6a2be711a70d7a1c4f34654fc285005c6a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090577/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090577/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25045665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Cardelli, Patrizia</contributor><creatorcontrib>Nunes, Lázaro Alessandro Soares</creatorcontrib><creatorcontrib>Grotto, Helena Zerlotti W.</creatorcontrib><creatorcontrib>Brenzikofer, René</creatorcontrib><creatorcontrib>Macedo, Denise Vaz</creatorcontrib><title>Hematological and Biochemical Markers of Iron Status in a Male, Young, Physically Active Population</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>The aim of this study was to establish reference intervals (RIs) for the hemogram and iron status biomarkers in a physically active population. The study population included male volunteers (n=150) with an average age of 19 ± 1 years who had participated in a regular and controlled exercise program for four months. Blood samples were collected to determine hematological parameters using a Sysmex XE-5000 analyzer (Sysmex, Kobe, Japan). Iron, total iron-binding capacity (TIBC), transferrin saturation and ferritin, and high-sensitivity C-reactive protein (CRP) concentrations in serum samples were measured using commercial kits (Roche Diagnostics, GmbH, Mannheim, Germany) and a Roche/Hitachi 902 analyzer. The RIs were established using the RefVal program 4.1b. The leucocyte count, TIBC, and CRP and ferritin concentrations exhibited higher RIs compared with those in a nonphysically active population. Thirty volunteers (outliers) were removed from the reference population due to blood abnormalities. Among the outliers, 46% exhibited higher CRP concentrations and lower concentrations of iron and reticulocyte hemoglobin compared with the nonphysically active population (P<0.001). Our results showed that it is important to establish RIs for certain laboratory parameters in a physically active population, especially for tests related to the inflammatory response and iron metabolism.</description><subject>Adult</subject><subject>Athletes</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - metabolism</subject><subject>Chronic illnesses</subject><subject>Colleges & universities</subject><subject>Exercise</subject><subject>Ferritins - blood</subject><subject>Health aspects</subject><subject>Hematologic Tests</subject><subject>Hematology</subject><subject>Humans</subject><subject>Identification and classification</subject><subject>Immune system</subject><subject>Iron</subject><subject>Iron - metabolism</subject><subject>Iron in the body</subject><subject>Japan</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Physical fitness</subject><subject>Proteins</subject><subject>Reference Values</subject><subject>Reference values (Medicine)</subject><subject>Sickle cell disease</subject><subject>Transferrins - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nunes, Lázaro Alessandro Soares</au><au>Grotto, Helena Zerlotti W.</au><au>Brenzikofer, René</au><au>Macedo, Denise Vaz</au><au>Cardelli, Patrizia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hematological and Biochemical Markers of Iron Status in a Male, Young, Physically Active Population</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2014</volume><issue>2014</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>The aim of this study was to establish reference intervals (RIs) for the hemogram and iron status biomarkers in a physically active population. The study population included male volunteers (n=150) with an average age of 19 ± 1 years who had participated in a regular and controlled exercise program for four months. Blood samples were collected to determine hematological parameters using a Sysmex XE-5000 analyzer (Sysmex, Kobe, Japan). Iron, total iron-binding capacity (TIBC), transferrin saturation and ferritin, and high-sensitivity C-reactive protein (CRP) concentrations in serum samples were measured using commercial kits (Roche Diagnostics, GmbH, Mannheim, Germany) and a Roche/Hitachi 902 analyzer. The RIs were established using the RefVal program 4.1b. The leucocyte count, TIBC, and CRP and ferritin concentrations exhibited higher RIs compared with those in a nonphysically active population. Thirty volunteers (outliers) were removed from the reference population due to blood abnormalities. Among the outliers, 46% exhibited higher CRP concentrations and lower concentrations of iron and reticulocyte hemoglobin compared with the nonphysically active population (P<0.001). Our results showed that it is important to establish RIs for certain laboratory parameters in a physically active population, especially for tests related to the inflammatory response and iron metabolism.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>25045665</pmid><doi>10.1155/2014/349182</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Athletes Biological markers Biomarkers Biomarkers - blood C-Reactive Protein - metabolism Chronic illnesses Colleges & universities Exercise Ferritins - blood Health aspects Hematologic Tests Hematology Humans Identification and classification Immune system Iron Iron - metabolism Iron in the body Japan Leukocyte Count Male Physical fitness Proteins Reference Values Reference values (Medicine) Sickle cell disease Transferrins - blood Young men |
| title | Hematological and Biochemical Markers of Iron Status in a Male, Young, Physically Active Population |
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