Fibroblast growth factor (Fgf) 21 is a novel target gene of the aryl hydrocarbon receptor (AhR)

The toxic effects of dioxins, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mainly through activation of the aryl hydrocarbon receptor (AhR) are well documented. Fibroblast growth factor (Fgf) 21 plays critical roles in metabolic adaptation to fasting by increasing lipid oxidation and ketogene...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicology and applied pharmacology 2014-07, Vol.278 (1), p.65-71
Hauptverfasser:	Cheng, Xingguo, Vispute, Saurabh G., Liu, Jie, Cheng, Christine, Kharitonenkov, Alexei, Klaassen, Curtis D.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ADIPOSE TISSUE Adipose Tissue, White - drug effects Adipose Tissue, White - metabolism AhR Animals Basic Helix-Loop-Helix Transcription Factors - agonists Basic Helix-Loop-Helix Transcription Factors - metabolism Binding Sites Biological and medical sciences Cell Line DEHP Diethylhexyl Phthalate - pharmacology DIOXIN DNA Dose-Response Relationship, Drug ENZYMES Fgf21 Fibroblast Growth Factors - deficiency Fibroblast Growth Factors - genetics Fibroblast Growth Factors - metabolism FIBROBLASTS GENES GROWTH FACTORS Hepatocytes - drug effects Hepatocytes - metabolism Humans HYDROCARBONS LIVER Liver - drug effects Liver - metabolism LIVER CELLS Male Medical sciences MESSENGER-RNA MICE Mice, Inbred C57BL Mice, Knockout Polychlorinated Dibenzodioxins - toxicity Promoter Regions, Genetic RECEPTORS Receptors, Aryl Hydrocarbon - agonists Receptors, Aryl Hydrocarbon - metabolism RNA, Messenger - metabolism Signal Transduction - drug effects TCDD TIME DEPENDENCE Time Factors TOXICITY Toxicology Up-Regulation White adipose tissue
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!