TLR5-deficient mice lack basal inflammatory and metabolic defects but exhibit impaired CD4 T cell responses to a flagellated pathogen

TLR5-deficient mice have been reported to develop spontaneous intestinal inflammation and metabolic abnormalities. However, we report that TLR5-deficient mice from two different animal colonies display no evidence of basal inflammatory disease, metabolic abnormalities, or enhanced resistance to Salm...

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Veröffentlicht in:	The Journal of immunology (1950) 2011-05, Vol.186 (9), p.5406-5412
Hauptverfasser:	Letran, Shirdi E, Lee, Seung-Joo, Atif, Shaikh M, Flores-Langarica, Adriana, Uematsu, Satoshi, Akira, Shizuo, Cunningham, Adam F, McSorley, Stephen J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD4-Positive T-Lymphocytes - immunology Flagellin - immunology Inflammation - immunology Mice Mice, Inbred C57BL Mice, Transgenic Salmonella Salmonella Infections, Animal - immunology Salmonella Infections, Animal - metabolism Salmonella Infections, Animal - pathology Toll-Like Receptor 5 - deficiency Toll-Like Receptor 5 - immunology
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