Global signatures of protein and mRNA expression levels
Cellular states are determined by differential expression of the cell's proteins. The relationship between protein and mRNA expression levels informs about the combined outcomes of translation and protein degradation which are, in addition to transcription and mRNA stability, essential contribu...
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| Veröffentlicht in: | Molecular bioSystems 2009-01, Vol.5 (12), p.1512-1526 |
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| container_title | Molecular bioSystems |
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| creator | de Sousa Abreu, Raquel Penalva, Luiz O Marcotte, Edward M Vogel, Christine |
| description | Cellular states are determined by differential expression of the cell's proteins. The relationship between protein and mRNA expression levels informs about the combined outcomes of translation and protein degradation which are, in addition to transcription and mRNA stability, essential contributors to gene expression regulation. This review summarizes the state of knowledge about large-scale measurements of absolute protein and mRNA expression levels, and the degree of correlation between the two parameters. We summarize the information that can be derived from comparison of protein and mRNA expression levels and discuss how corresponding sequence characteristics suggest modes of regulation. |
| doi_str_mv | 10.1039/b908315d |
| format | Article |
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| ispartof | Molecular bioSystems, 2009-01, Vol.5 (12), p.1512-1526 |
| issn | 1742-206X 1742-2051 |
| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Computational Biology - methods Escherichia coli - genetics Escherichia coli - metabolism Humans Protein Biosynthesis Proteins - genetics Proteins - metabolism RNA, Messenger - biosynthesis RNA, Messenger - genetics Ubiquitination Yeasts - genetics Yeasts - metabolism |
| title | Global signatures of protein and mRNA expression levels |
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