Flt3 signaling regulates the proliferation, survival, and maintenance of multipotent hematopoietic progenitors that generate B cell precursors

Flt3 signaling plays a crucial role in regulating the survival and differentiation of lymphoid progenitors into B cell precursors (BCPs) in bone marrow. To define further the role of Flt3 signaling in lymphoid progenitor survival, mice deficient in Flt3 ligand that also expressed a Bcl2 transgene (...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Experimental hematology 2014-05, Vol.42 (5), p.380-393.e3
Hauptverfasser:	Dolence, Joseph J, Gwin, Kimberly A, Shapiro, Mariya B, Medina, Kay L
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Cell Proliferation Cell Survival - genetics fms-Like Tyrosine Kinase 3 - genetics fms-Like Tyrosine Kinase 3 - metabolism Hematology, Oncology and Palliative Medicine Mice Mice, Knockout Multipotent Stem Cells - cytology Multipotent Stem Cells - metabolism Precursor Cells, B-Lymphoid - cytology Precursor Cells, B-Lymphoid - metabolism Proto-Oncogene Proteins c-bcl-2 - biosynthesis Proto-Oncogene Proteins c-bcl-2 - genetics Transgenes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!