Collagen‐induced arthritis: severity and immune response attenuation using multivalent N‐acetyl glucosamine

Summary Rheumatoid arthritis is an autoimmunity leading to considerable impairment of quality of life. N‐acetyl glucosamine (GlcNAc) has been described previously as a potent modulator of experimental arthritis in animal models and is used for osteoarthritis treatment in humans, praised for its lack...

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Veröffentlicht in:	Clinical and experimental immunology 2014-07, Vol.177 (1), p.121-133
Hauptverfasser:	Richter, J., Čapková, K., Hříbalová, V., Vannucci, L., Danyi, I., Malý, M., Fišerová, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - administration & dosage Animals Antigen-Presenting Cells - drug effects Antigen-Presenting Cells - immunology Arthritis, Experimental - drug therapy Arthritis, Experimental - immunology Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - immunology B-Lymphocytes - drug effects B-Lymphocytes - immunology Cell Differentiation - drug effects Cells, Cultured CIA clinical scoring Collagen cytokines Cytokines - metabolism Disease Models, Animal Female GlcNAc glycoconjugates Humans humoral response Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Male Medical research Mice Mice, Inbred DBA NK Cell Lectin-Like Receptor Subfamily K - metabolism Original Rheumatoid arthritis Synovial Membrane - drug effects Synovial Membrane - immunology T-Lymphocytes - drug effects T-Lymphocytes - immunology
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