RIP3 overexpression sensitizes human breast cancer cells to parthenolide in vitro via intracellular ROS accumulation

Aim： Receptor-interacting protein 3 （RIP3） is involved in tumor necrosis factor receptor signaling, and results in NF-KB-mediated prosurvival signaling and programmed cell death. The aim of this study was to determine whether overexpression of the RIP3 gene could sensitize human breast cancer cells...

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Veröffentlicht in:	Acta pharmacologica Sinica 2014-07, Vol.35 (7), p.929-936
Hauptverfasser:	Lu, Can, Zhou, Li-yan, Xu, Hui-jun, Chen, Xing-yu, Tong, Zhong-sheng, Liu, Xiao-dong, Jia, Yong-sheng, Chen, Yue
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antineoplastic Agents - pharmacology Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Breast - drug effects Breast - metabolism Breast - pathology Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Female Gene Deletion Gene Expression Regulation, Neoplastic Humans Immunology Internal Medicine Medical Microbiology Original original-article Pharmacology/Toxicology Reactive Oxygen Species - metabolism Receptor-Interacting Protein Serine-Threonine Kinases - genetics Receptor-Interacting Protein Serine-Threonine Kinases - metabolism ROS Sesquiterpenes - pharmacology Up-Regulation Vaccine 人乳腺癌细胞体外敏感性白菊积累细胞内过度
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