Acute coronary syndrome after infliximab therapy in a patient with Crohn's disease
Infliximab is a potent anti-TNF antibody, which is used with great success in Crohn's disease patients. Since its release in clinical practice, several adverse reactions have been observed. The interest in possible consequences of its administration is still high because of the recent introduct...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2006-10, Vol.12 (38), p.6235-6238 |
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| container_issue | 38 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Panteris, Vasilios Perdiou, Anna Tsirimpis, Vasilios Karamanolis, Demetrios-Georgios |
| description | Infliximab is a potent anti-TNF antibody, which is used with great success in Crohn's disease patients. Since its release in clinical practice, several adverse reactions have been observed. The interest in possible consequences of its administration is still high because of the recent introduction of the drug for the long-term maintenance therapy of refractory luminal and fistulizing Crohn's disease. We present a case of acute coronary syndrome (non-STEMI) in a patient with corticoid resistant Crohn's disease after his first dose of infliximab. By reviewing the scant articles that exist in the literature on this topic we made an effort to delineate the possible mechanisms of this phenomenon. |
| doi_str_mv | 10.3748/wjg.v12.i38.6235 |
| format | Article |
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Since its release in clinical practice, several adverse reactions have been observed. The interest in possible consequences of its administration is still high because of the recent introduction of the drug for the long-term maintenance therapy of refractory luminal and fistulizing Crohn's disease. We present a case of acute coronary syndrome (non-STEMI) in a patient with corticoid resistant Crohn's disease after his first dose of infliximab. 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| ispartof | World journal of gastroenterology : WJG, 2006-10, Vol.12 (38), p.6235-6238 |
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| source | MEDLINE; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Anti-Inflammatory Agents - adverse effects Antibodies, Monoclonal - adverse effects Case Report Crohn Disease - drug therapy Humans Infliximab Male Myocardial Infarction - etiology Tumor Necrosis Factor-alpha - antagonists & inhibitors |
| title | Acute coronary syndrome after infliximab therapy in a patient with Crohn's disease |
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