Interrelationship between chromosome 8 aneuploidy, C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma

AIM： To investigate chromosome 8 numerical aberrations, C-MYC oncogene alterations and its expression in gastric cancer and to correlate these findings with histopathological characteristics of gastric tumors. METHODS： Specimens were collected surgically from seven patients with gastric adenocarcino...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	World journal of gastroenterology : WJG 2006-10, Vol.12 (38), p.6207-6211
Hauptverfasser:	Calcagno, Danielle-Queiroz, Leal, Mariana-Ferreira, Seabra, Aline-Damaceno, Khayat, Andre-Salim, Chen, Elizabeth Suchi, Demachki, Samia, Assumpção, Paulo Pimentel, Faria, Mario Henrique Girão, Rabenhorst, Silvia Helena Barem, Ferreira, Márcia Valéria Pitombeira, de Arruda Cardoso Smith, Marília, Burbano, Rommel-Rodríguez
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adult Aged Aneuploidy Brazil Chromosomes, Human, Pair 8 Gene Amplification Gene Expression Regulation, Neoplastic Genes, myc Humans Immunohistochemistry In Situ Hybridization, Fluorescence Middle Aged Rapid Communication Stomach Neoplasms - genetics 基因表达染色体病理机制
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	6211
container_issue	38
container_start_page	6207
container_title	World journal of gastroenterology : WJG
container_volume	12
creator	Calcagno, Danielle-Queiroz Leal, Mariana-Ferreira Seabra, Aline-Damaceno Khayat, Andre-Salim Chen, Elizabeth Suchi Demachki, Samia Assumpção, Paulo Pimentel Faria, Mario Henrique Girão Rabenhorst, Silvia Helena Barem Ferreira, Márcia Valéria Pitombeira de Arruda Cardoso Smith, Marília Burbano, Rommel-Rodríguez
description	AIM： To investigate chromosome 8 numerical aberrations, C-MYC oncogene alterations and its expression in gastric cancer and to correlate these findings with histopathological characteristics of gastric tumors. METHODS： Specimens were collected surgically from seven patients with gastric adenocarcinomas. Immunostaining for C-MYC and dual-color fluorescence in situ hybridization （FISH） for C-MYC gene and chromosome 8 centromere were performed. RESULTS： All the cases showed chromosome 8 aneuploidy and C-MYC amplification, in both the diffuse and intestinal histopathological types of Lauren. No significant difference （P 〈 0.05） was observed between the level of chromosome 8 ploidy and the site, stage or histological type of the adenocarcinomas. C-MYC high amplification, like homogeneously stained regions （HSRs） and double minutes （DMs）, was observed only in the intestinal-type. Structural rearrangement of C-MYC, like translocation, was observed only in the diffuse type. Regarding C-MYC gene, a significant difference （P 〈 0.05） was observed between the two histological types. The C-MYC protein was expressed in all the studied cases. In the intestinaltype the C-MYC immunoreactivity was localized only in the nucleus and in the diffuse type in the nucleus and cytoplasm. CONCLUSION： Distinct patterns of alterations between intestinal and diffuse types of gastric tumors support the hypothesis that these types follow different genetic pathways.
doi_str_mv	10.3748/wjg.v12.i38.6207
format	Article
fullrecord	<record><control><sourceid>wanfang_jour_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4088119</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>23139972</cqvip_id><wanfj_id>wjg200638021</wanfj_id><sourcerecordid>wjg200638021</sourcerecordid><originalsourceid>FETCH-LOGICAL-c408t-8e972240cf42b48ecb831b8d8c94fb6180a7094671ce42aad48c06d39d5188e33</originalsourceid><addsrcrecordid>eNpVUcuO0zAUtRCIKQN7VshCiBUpfjVxNkhQ8RhpEBtYsLIc-6ZxSeyMnbQMP8Ov4tCKh2TJi_O4596D0GNK1rwS8uVxv1sfKFs7LtclI9UdtGKM1gWTgtxFK0pIVdScVRfoQUp7QhjnG3YfXdCK8JLX1Qr9vPITxAi9nlzwqXMjbmA6AnhsuhiGkMIAWGLtYR774OztC7wtPn7dYj2MvWud-S3MuMXOmwg6gcXwfYyQ0gK45Vl3cHbWfcJt9sQ-xKmD6PGbqH-4Hh_d1OGdTlN0BmsLPhgdjfNh0A_RvTbr4NH5v0Rf3r39vP1QXH96f7V9fV0YQeRUSKgrxgQxrWCNkGAayWkjrTS1aJuSSqIrUouyogYE09oKaUhpeW03VErg_BK9OvmOczOANeCnqHs1RjfoeKuCdup_xLtO7cJB5fGS0jobPDsZHLVvtd-pfZijz5FVLokRUnJJGM205-c5MdzMkCY1uGSg7_OBw5xUKetNJotMJCeiiSGlCO2fLJSopfzFV-XyVS5fLeVnyZN_d_grOLedCU_Pnl3wuxuXUzbafGtdD4pxyut8RP4L1tu8Nw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68950064</pqid></control><display><type>article</type><title>Interrelationship between chromosome 8 aneuploidy, C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma</title><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Calcagno, Danielle-Queiroz ; Leal, Mariana-Ferreira ; Seabra, Aline-Damaceno ; Khayat, Andre-Salim ; Chen, Elizabeth Suchi ; Demachki, Samia ; Assumpção, Paulo Pimentel ; Faria, Mario Henrique Girão ; Rabenhorst, Silvia Helena Barem ; Ferreira, Márcia Valéria Pitombeira ; de Arruda Cardoso Smith, Marília ; Burbano, Rommel-Rodríguez</creator><creatorcontrib>Calcagno, Danielle-Queiroz ; Leal, Mariana-Ferreira ; Seabra, Aline-Damaceno ; Khayat, Andre-Salim ; Chen, Elizabeth Suchi ; Demachki, Samia ; Assumpção, Paulo Pimentel ; Faria, Mario Henrique Girão ; Rabenhorst, Silvia Helena Barem ; Ferreira, Márcia Valéria Pitombeira ; de Arruda Cardoso Smith, Marília ; Burbano, Rommel-Rodríguez</creatorcontrib><description>AIM： To investigate chromosome 8 numerical aberrations, C-MYC oncogene alterations and its expression in gastric cancer and to correlate these findings with histopathological characteristics of gastric tumors. METHODS： Specimens were collected surgically from seven patients with gastric adenocarcinomas. Immunostaining for C-MYC and dual-color fluorescence in situ hybridization （FISH） for C-MYC gene and chromosome 8 centromere were performed. RESULTS： All the cases showed chromosome 8 aneuploidy and C-MYC amplification, in both the diffuse and intestinal histopathological types of Lauren. No significant difference （P 〈 0.05） was observed between the level of chromosome 8 ploidy and the site, stage or histological type of the adenocarcinomas. C-MYC high amplification, like homogeneously stained regions （HSRs） and double minutes （DMs）, was observed only in the intestinal-type. Structural rearrangement of C-MYC, like translocation, was observed only in the diffuse type. Regarding C-MYC gene, a significant difference （P 〈 0.05） was observed between the two histological types. The C-MYC protein was expressed in all the studied cases. In the intestinaltype the C-MYC immunoreactivity was localized only in the nucleus and in the diffuse type in the nucleus and cytoplasm. CONCLUSION： Distinct patterns of alterations between intestinal and diffuse types of gastric tumors support the hypothesis that these types follow different genetic pathways.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v12.i38.6207</identifier><identifier>PMID: 17036397</identifier><language>eng</language><publisher>United States: Genetics Division, Department of Morphology, Federal University of S(a)o Paulo, S(a)o Paulo, SP, Brazil</publisher><subject>Adenocarcinoma - genetics ; Adult ; Aged ; Aneuploidy ; Brazil ; Chromosomes, Human, Pair 8 ; Gene Amplification ; Gene Expression Regulation, Neoplastic ; Genes, myc ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Middle Aged ; Rapid Communication ; Stomach Neoplasms - genetics ; 基因表达 ; 染色体 ; 病理机制</subject><ispartof>World journal of gastroenterology : WJG, 2006-10, Vol.12 (38), p.6207-6211</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2006 Baishideng Publishing Group Co., Limited. All rights reserved. 2006</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-8e972240cf42b48ecb831b8d8c94fb6180a7094671ce42aad48c06d39d5188e33</citedby><cites>FETCH-LOGICAL-c408t-8e972240cf42b48ecb831b8d8c94fb6180a7094671ce42aad48c06d39d5188e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4088119/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4088119/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17036397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Calcagno, Danielle-Queiroz</creatorcontrib><creatorcontrib>Leal, Mariana-Ferreira</creatorcontrib><creatorcontrib>Seabra, Aline-Damaceno</creatorcontrib><creatorcontrib>Khayat, Andre-Salim</creatorcontrib><creatorcontrib>Chen, Elizabeth Suchi</creatorcontrib><creatorcontrib>Demachki, Samia</creatorcontrib><creatorcontrib>Assumpção, Paulo Pimentel</creatorcontrib><creatorcontrib>Faria, Mario Henrique Girão</creatorcontrib><creatorcontrib>Rabenhorst, Silvia Helena Barem</creatorcontrib><creatorcontrib>Ferreira, Márcia Valéria Pitombeira</creatorcontrib><creatorcontrib>de Arruda Cardoso Smith, Marília</creatorcontrib><creatorcontrib>Burbano, Rommel-Rodríguez</creatorcontrib><title>Interrelationship between chromosome 8 aneuploidy, C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM： To investigate chromosome 8 numerical aberrations, C-MYC oncogene alterations and its expression in gastric cancer and to correlate these findings with histopathological characteristics of gastric tumors. METHODS： Specimens were collected surgically from seven patients with gastric adenocarcinomas. Immunostaining for C-MYC and dual-color fluorescence in situ hybridization （FISH） for C-MYC gene and chromosome 8 centromere were performed. RESULTS： All the cases showed chromosome 8 aneuploidy and C-MYC amplification, in both the diffuse and intestinal histopathological types of Lauren. No significant difference （P 〈 0.05） was observed between the level of chromosome 8 ploidy and the site, stage or histological type of the adenocarcinomas. C-MYC high amplification, like homogeneously stained regions （HSRs） and double minutes （DMs）, was observed only in the intestinal-type. Structural rearrangement of C-MYC, like translocation, was observed only in the diffuse type. Regarding C-MYC gene, a significant difference （P 〈 0.05） was observed between the two histological types. The C-MYC protein was expressed in all the studied cases. In the intestinaltype the C-MYC immunoreactivity was localized only in the nucleus and in the diffuse type in the nucleus and cytoplasm. CONCLUSION： Distinct patterns of alterations between intestinal and diffuse types of gastric tumors support the hypothesis that these types follow different genetic pathways.</description><subject>Adenocarcinoma - genetics</subject><subject>Adult</subject><subject>Aged</subject><subject>Aneuploidy</subject><subject>Brazil</subject><subject>Chromosomes, Human, Pair 8</subject><subject>Gene Amplification</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genes, myc</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Middle Aged</subject><subject>Rapid Communication</subject><subject>Stomach Neoplasms - genetics</subject><subject>基因表达</subject><subject>染色体</subject><subject>病理机制</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUcuO0zAUtRCIKQN7VshCiBUpfjVxNkhQ8RhpEBtYsLIc-6ZxSeyMnbQMP8Ov4tCKh2TJi_O4596D0GNK1rwS8uVxv1sfKFs7LtclI9UdtGKM1gWTgtxFK0pIVdScVRfoQUp7QhjnG3YfXdCK8JLX1Qr9vPITxAi9nlzwqXMjbmA6AnhsuhiGkMIAWGLtYR774OztC7wtPn7dYj2MvWud-S3MuMXOmwg6gcXwfYyQ0gK45Vl3cHbWfcJt9sQ-xKmD6PGbqH-4Hh_d1OGdTlN0BmsLPhgdjfNh0A_RvTbr4NH5v0Rf3r39vP1QXH96f7V9fV0YQeRUSKgrxgQxrWCNkGAayWkjrTS1aJuSSqIrUouyogYE09oKaUhpeW03VErg_BK9OvmOczOANeCnqHs1RjfoeKuCdup_xLtO7cJB5fGS0jobPDsZHLVvtd-pfZijz5FVLokRUnJJGM205-c5MdzMkCY1uGSg7_OBw5xUKetNJotMJCeiiSGlCO2fLJSopfzFV-XyVS5fLeVnyZN_d_grOLedCU_Pnl3wuxuXUzbafGtdD4pxyut8RP4L1tu8Nw</recordid><startdate>20061014</startdate><enddate>20061014</enddate><creator>Calcagno, Danielle-Queiroz</creator><creator>Leal, Mariana-Ferreira</creator><creator>Seabra, Aline-Damaceno</creator><creator>Khayat, Andre-Salim</creator><creator>Chen, Elizabeth Suchi</creator><creator>Demachki, Samia</creator><creator>Assumpção, Paulo Pimentel</creator><creator>Faria, Mario Henrique Girão</creator><creator>Rabenhorst, Silvia Helena Barem</creator><creator>Ferreira, Márcia Valéria Pitombeira</creator><creator>de Arruda Cardoso Smith, Marília</creator><creator>Burbano, Rommel-Rodríguez</creator><general>Genetics Division, Department of Morphology, Federal University of S(a)o Paulo, S(a)o Paulo, SP, Brazil</general><general>Human Cytogenetics and Toxicological Genetics Laboratory, Department of Biology, Center of Biological Sciences, Federal University of Pará, Belém, PA, Brazil%Genetics Division, Department of Morphology, Federal University of S(a)o Paulo, S(a)o Paulo, SP, Brazil%Department of Pathology and Surgery Service,Federal University of Pará, Belém, PA, Brazil%Jo(a)o de Barros Barreto University Hospital, Federal University of Pará, Belém, PA, Brazil%Molecular Genetics Laboratory Department of Pathology, Medical School, Federal University of Ceará, Fortaleza, CE, Brazil%Human Cytogenetics and Toxicological Genetics Laboratory, Department of Biology, Center of Biological Sciences, Federal University of Pará, Belém, PA, Brazil</general><general>Baishideng Publishing Group Co., Limited</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20061014</creationdate><title>Interrelationship between chromosome 8 aneuploidy, C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma</title><author>Calcagno, Danielle-Queiroz ; Leal, Mariana-Ferreira ; Seabra, Aline-Damaceno ; Khayat, Andre-Salim ; Chen, Elizabeth Suchi ; Demachki, Samia ; Assumpção, Paulo Pimentel ; Faria, Mario Henrique Girão ; Rabenhorst, Silvia Helena Barem ; Ferreira, Márcia Valéria Pitombeira ; de Arruda Cardoso Smith, Marília ; Burbano, Rommel-Rodríguez</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-8e972240cf42b48ecb831b8d8c94fb6180a7094671ce42aad48c06d39d5188e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adenocarcinoma - genetics</topic><topic>Adult</topic><topic>Aged</topic><topic>Aneuploidy</topic><topic>Brazil</topic><topic>Chromosomes, Human, Pair 8</topic><topic>Gene Amplification</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Genes, myc</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Middle Aged</topic><topic>Rapid Communication</topic><topic>Stomach Neoplasms - genetics</topic><topic>基因表达</topic><topic>染色体</topic><topic>病理机制</topic><toplevel>online_resources</toplevel><creatorcontrib>Calcagno, Danielle-Queiroz</creatorcontrib><creatorcontrib>Leal, Mariana-Ferreira</creatorcontrib><creatorcontrib>Seabra, Aline-Damaceno</creatorcontrib><creatorcontrib>Khayat, Andre-Salim</creatorcontrib><creatorcontrib>Chen, Elizabeth Suchi</creatorcontrib><creatorcontrib>Demachki, Samia</creatorcontrib><creatorcontrib>Assumpção, Paulo Pimentel</creatorcontrib><creatorcontrib>Faria, Mario Henrique Girão</creatorcontrib><creatorcontrib>Rabenhorst, Silvia Helena Barem</creatorcontrib><creatorcontrib>Ferreira, Márcia Valéria Pitombeira</creatorcontrib><creatorcontrib>de Arruda Cardoso Smith, Marília</creatorcontrib><creatorcontrib>Burbano, Rommel-Rodríguez</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Calcagno, Danielle-Queiroz</au><au>Leal, Mariana-Ferreira</au><au>Seabra, Aline-Damaceno</au><au>Khayat, Andre-Salim</au><au>Chen, Elizabeth Suchi</au><au>Demachki, Samia</au><au>Assumpção, Paulo Pimentel</au><au>Faria, Mario Henrique Girão</au><au>Rabenhorst, Silvia Helena Barem</au><au>Ferreira, Márcia Valéria Pitombeira</au><au>de Arruda Cardoso Smith, Marília</au><au>Burbano, Rommel-Rodríguez</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interrelationship between chromosome 8 aneuploidy, C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2006-10-14</date><risdate>2006</risdate><volume>12</volume><issue>38</issue><spage>6207</spage><epage>6211</epage><pages>6207-6211</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM： To investigate chromosome 8 numerical aberrations, C-MYC oncogene alterations and its expression in gastric cancer and to correlate these findings with histopathological characteristics of gastric tumors. METHODS： Specimens were collected surgically from seven patients with gastric adenocarcinomas. Immunostaining for C-MYC and dual-color fluorescence in situ hybridization （FISH） for C-MYC gene and chromosome 8 centromere were performed. RESULTS： All the cases showed chromosome 8 aneuploidy and C-MYC amplification, in both the diffuse and intestinal histopathological types of Lauren. No significant difference （P 〈 0.05） was observed between the level of chromosome 8 ploidy and the site, stage or histological type of the adenocarcinomas. C-MYC high amplification, like homogeneously stained regions （HSRs） and double minutes （DMs）, was observed only in the intestinal-type. Structural rearrangement of C-MYC, like translocation, was observed only in the diffuse type. Regarding C-MYC gene, a significant difference （P 〈 0.05） was observed between the two histological types. The C-MYC protein was expressed in all the studied cases. In the intestinaltype the C-MYC immunoreactivity was localized only in the nucleus and in the diffuse type in the nucleus and cytoplasm. CONCLUSION： Distinct patterns of alterations between intestinal and diffuse types of gastric tumors support the hypothesis that these types follow different genetic pathways.</abstract><cop>United States</cop><pub>Genetics Division, Department of Morphology, Federal University of S(a)o Paulo, S(a)o Paulo, SP, Brazil</pub><pmid>17036397</pmid><doi>10.3748/wjg.v12.i38.6207</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext	fulltext
identifier	ISSN: 1007-9327
ispartof	World journal of gastroenterology : WJG, 2006-10, Vol.12 (38), p.6207-6211
issn	1007-9327 2219-2840
language	eng
recordid	cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4088119
source	MEDLINE; PubMed Central; Alma/SFX Local Collection
subjects	Adenocarcinoma - genetics Adult Aged Aneuploidy Brazil Chromosomes, Human, Pair 8 Gene Amplification Gene Expression Regulation, Neoplastic Genes, myc Humans Immunohistochemistry In Situ Hybridization, Fluorescence Middle Aged Rapid Communication Stomach Neoplasms - genetics 基因表达染色体病理机制
title	Interrelationship between chromosome 8 aneuploidy, C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T01%3A01%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wanfang_jour_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Interrelationship%20between%20chromosome%208%20aneuploidy,%20C-MYC%20amplification%20and%20increased%20expression%20in%20individuals%20from%20northern%20Brazil%20with%20gastric%20adenocarcinoma&rft.jtitle=World%20journal%20of%20gastroenterology%20:%20WJG&rft.au=Calcagno,%20Danielle-Queiroz&rft.date=2006-10-14&rft.volume=12&rft.issue=38&rft.spage=6207&rft.epage=6211&rft.pages=6207-6211&rft.issn=1007-9327&rft.eissn=2219-2840&rft_id=info:doi/10.3748/wjg.v12.i38.6207&rft_dat=%3Cwanfang_jour_pubme%3Ewjg200638021%3C/wanfang_jour_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68950064&rft_id=info:pmid/17036397&rft_cqvip_id=23139972&rft_wanfj_id=wjg200638021&rfr_iscdi=true