Expression of altered retinoblastoma protein inversely correlates with tumor invasion in gastric carcinoma
AIM： To investigate the clinical and pathological significance of altered retinoblastoma （Rb） encoding protein （pRb） in gastric carcinoma. METHODS： Expression of altered pRb was analyzed in 91 patients with gastric adenocarcinoma by immunohistochemistry. RESULTS： Sixty-five percent （59/91） of the tu...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2006-11, Vol.12 (44), p.7188-7191 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Chou, Nan-Hua Chen, Hui-Chun Chou, Nan-Song Hsu, Ping-I Tseng, Hui-Hwa |
| description | AIM： To investigate the clinical and pathological significance of altered retinoblastoma （Rb） encoding protein （pRb） in gastric carcinoma.
METHODS： Expression of altered pRb was analyzed in 91 patients with gastric adenocarcinoma by immunohistochemistry. RESULTS： Sixty-five percent （59/91） of the tumors were positively stained and the staining in tumor nuclei of gastric carcinoma ranged 0%-90%. Moreover, strong expression of altered pRb was found in 35% （6/17）, 24% （5/21）, 17% （8/46） and 0% （0/7） of T1, T2, T3 and T4 gastric carcinomas, respectively. Altered pRb expression was inversely correlated with the depth of tumor invasion （P = 0.047）. Degree of immunoreactivity had no significant correlation with tumor grade, node metastasis and distant metastasis. In terms of prognostic significance, univariate analysis showed that poor differentiation [41 （66.1%） vs 34 （42.5%） P = 0.051], advanced tumor stage （P 〈 0.001） and weakly altered pRb expression [17 （80.5%） vs 58 （49.6%） P = 0.044] were associated with worse prognosis in these patients. However, multivariate analysis revealed that advanced tumor stage was the only independent poor prognostic factor （P 〈 0.001）.
CONCLUSION： The mutation of Rb gene is frequent in gastric carcinoma. The expression of altered pRb inversely correlates with tumor invasion and is not an independent prognostic marker in gastric adenocarcinoma. |
| doi_str_mv | 10.3748/wjg.v12.i44.7188 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4087784</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>23386555</cqvip_id><sourcerecordid>68197706</sourcerecordid><originalsourceid>FETCH-LOGICAL-c421t-357fe65fb97d2a289543b1681e79acca6e886dd4c4f29f27703facc892368a0e3</originalsourceid><addsrcrecordid>eNpVkUtr3DAURkVpaaZJ910V0UV3nuhlS94USkgfEMimWQtZvvJoKlsTSTNJ_n01zdDHSqD7fedeOAi9o2TNpVCXD9tpfaBs7YVYS6rUC7RijPYNU4K8RCtKiGx6zuQZepPzlhDGecteozMqKadCtSu0vX7cJcjZxwVHh00okGDECYpf4hBMLnE2eJdiAb9gvxwgZQhP2MaUIJgCGT_4ssFlP8d0nJvfqJqdajd5i61JtrJmc4FeORMyvD295-juy_WPq2_Nze3X71efbxorGC0Nb6WDrnVDL0dmmOpbwQfaKQqyN9aaDpTqxlFY4VjvmJSEu_qvesY7ZQjwc_TpmbvbDzOMFpaSTNC75GeTnnQ0Xv8_WfxGT_GgBVFSKlEBH0-AFO_3kIuefbYQglkg7rOut_R1bVeD5DloU8w5gfuzhBJ9FKSrIF0F6SpIHwXVyvt_j_tbOBmpgQ8n5iYu071fJj0Y-9P5ALrqU13btvwXXDmdWw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68197706</pqid></control><display><type>article</type><title>Expression of altered retinoblastoma protein inversely correlates with tumor invasion in gastric carcinoma</title><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Chou, Nan-Hua ; Chen, Hui-Chun ; Chou, Nan-Song ; Hsu, Ping-I ; Tseng, Hui-Hwa</creator><creatorcontrib>Chou, Nan-Hua ; Chen, Hui-Chun ; Chou, Nan-Song ; Hsu, Ping-I ; Tseng, Hui-Hwa</creatorcontrib><description>AIM： To investigate the clinical and pathological significance of altered retinoblastoma （Rb） encoding protein （pRb） in gastric carcinoma.
METHODS： Expression of altered pRb was analyzed in 91 patients with gastric adenocarcinoma by immunohistochemistry. RESULTS： Sixty-five percent （59/91） of the tumors were positively stained and the staining in tumor nuclei of gastric carcinoma ranged 0%-90%. Moreover, strong expression of altered pRb was found in 35% （6/17）, 24% （5/21）, 17% （8/46） and 0% （0/7） of T1, T2, T3 and T4 gastric carcinomas, respectively. Altered pRb expression was inversely correlated with the depth of tumor invasion （P = 0.047）. Degree of immunoreactivity had no significant correlation with tumor grade, node metastasis and distant metastasis. In terms of prognostic significance, univariate analysis showed that poor differentiation [41 （66.1%） vs 34 （42.5%） P = 0.051], advanced tumor stage （P 〈 0.001） and weakly altered pRb expression [17 （80.5%） vs 58 （49.6%） P = 0.044] were associated with worse prognosis in these patients. However, multivariate analysis revealed that advanced tumor stage was the only independent poor prognostic factor （P 〈 0.001）.
CONCLUSION： The mutation of Rb gene is frequent in gastric carcinoma. The expression of altered pRb inversely correlates with tumor invasion and is not an independent prognostic marker in gastric adenocarcinoma.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v12.i44.7188</identifier><identifier>PMID: 17131485</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Co., Limited</publisher><subject>Adenocarcinoma - diagnosis ; Adenocarcinoma - metabolism ; Adenocarcinoma - pathology ; Adult ; Aged ; Aged, 80 and over ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Middle Aged ; Mutation ; Neoplasm Invasiveness ; Prognosis ; Rapid Communication ; Retinoblastoma Protein - genetics ; Retinoblastoma Protein - metabolism ; Stomach Neoplasms - diagnosis ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - pathology ; 眼癌 ; 肿瘤细胞入侵 ; 肿瘤细胞转移 ; 胃癌 ; 蛋白质</subject><ispartof>World journal of gastroenterology : WJG, 2006-11, Vol.12 (44), p.7188-7191</ispartof><rights>2006 Baishideng Publishing Group Co., Limited. All rights reserved. 2006</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-357fe65fb97d2a289543b1681e79acca6e886dd4c4f29f27703facc892368a0e3</citedby><cites>FETCH-LOGICAL-c421t-357fe65fb97d2a289543b1681e79acca6e886dd4c4f29f27703facc892368a0e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087784/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087784/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17131485$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chou, Nan-Hua</creatorcontrib><creatorcontrib>Chen, Hui-Chun</creatorcontrib><creatorcontrib>Chou, Nan-Song</creatorcontrib><creatorcontrib>Hsu, Ping-I</creatorcontrib><creatorcontrib>Tseng, Hui-Hwa</creatorcontrib><title>Expression of altered retinoblastoma protein inversely correlates with tumor invasion in gastric carcinoma</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM： To investigate the clinical and pathological significance of altered retinoblastoma （Rb） encoding protein （pRb） in gastric carcinoma.
METHODS： Expression of altered pRb was analyzed in 91 patients with gastric adenocarcinoma by immunohistochemistry. RESULTS： Sixty-five percent （59/91） of the tumors were positively stained and the staining in tumor nuclei of gastric carcinoma ranged 0%-90%. Moreover, strong expression of altered pRb was found in 35% （6/17）, 24% （5/21）, 17% （8/46） and 0% （0/7） of T1, T2, T3 and T4 gastric carcinomas, respectively. Altered pRb expression was inversely correlated with the depth of tumor invasion （P = 0.047）. Degree of immunoreactivity had no significant correlation with tumor grade, node metastasis and distant metastasis. In terms of prognostic significance, univariate analysis showed that poor differentiation [41 （66.1%） vs 34 （42.5%） P = 0.051], advanced tumor stage （P 〈 0.001） and weakly altered pRb expression [17 （80.5%） vs 58 （49.6%） P = 0.044] were associated with worse prognosis in these patients. However, multivariate analysis revealed that advanced tumor stage was the only independent poor prognostic factor （P 〈 0.001）.
CONCLUSION： The mutation of Rb gene is frequent in gastric carcinoma. The expression of altered pRb inversely correlates with tumor invasion and is not an independent prognostic marker in gastric adenocarcinoma.</description><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Neoplasm Invasiveness</subject><subject>Prognosis</subject><subject>Rapid Communication</subject><subject>Retinoblastoma Protein - genetics</subject><subject>Retinoblastoma Protein - metabolism</subject><subject>Stomach Neoplasms - diagnosis</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - pathology</subject><subject>眼癌</subject><subject>肿瘤细胞入侵</subject><subject>肿瘤细胞转移</subject><subject>胃癌</subject><subject>蛋白质</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtr3DAURkVpaaZJ910V0UV3nuhlS94USkgfEMimWQtZvvJoKlsTSTNJ_n01zdDHSqD7fedeOAi9o2TNpVCXD9tpfaBs7YVYS6rUC7RijPYNU4K8RCtKiGx6zuQZepPzlhDGecteozMqKadCtSu0vX7cJcjZxwVHh00okGDECYpf4hBMLnE2eJdiAb9gvxwgZQhP2MaUIJgCGT_4ssFlP8d0nJvfqJqdajd5i61JtrJmc4FeORMyvD295-juy_WPq2_Nze3X71efbxorGC0Nb6WDrnVDL0dmmOpbwQfaKQqyN9aaDpTqxlFY4VjvmJSEu_qvesY7ZQjwc_TpmbvbDzOMFpaSTNC75GeTnnQ0Xv8_WfxGT_GgBVFSKlEBH0-AFO_3kIuefbYQglkg7rOut_R1bVeD5DloU8w5gfuzhBJ9FKSrIF0F6SpIHwXVyvt_j_tbOBmpgQ8n5iYu071fJj0Y-9P5ALrqU13btvwXXDmdWw</recordid><startdate>20061128</startdate><enddate>20061128</enddate><creator>Chou, Nan-Hua</creator><creator>Chen, Hui-Chun</creator><creator>Chou, Nan-Song</creator><creator>Hsu, Ping-I</creator><creator>Tseng, Hui-Hwa</creator><general>Baishideng Publishing Group Co., Limited</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20061128</creationdate><title>Expression of altered retinoblastoma protein inversely correlates with tumor invasion in gastric carcinoma</title><author>Chou, Nan-Hua ; Chen, Hui-Chun ; Chou, Nan-Song ; Hsu, Ping-I ; Tseng, Hui-Hwa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-357fe65fb97d2a289543b1681e79acca6e886dd4c4f29f27703facc892368a0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Neoplasm Invasiveness</topic><topic>Prognosis</topic><topic>Rapid Communication</topic><topic>Retinoblastoma Protein - genetics</topic><topic>Retinoblastoma Protein - metabolism</topic><topic>Stomach Neoplasms - diagnosis</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - pathology</topic><topic>眼癌</topic><topic>肿瘤细胞入侵</topic><topic>肿瘤细胞转移</topic><topic>胃癌</topic><topic>蛋白质</topic><toplevel>online_resources</toplevel><creatorcontrib>Chou, Nan-Hua</creatorcontrib><creatorcontrib>Chen, Hui-Chun</creatorcontrib><creatorcontrib>Chou, Nan-Song</creatorcontrib><creatorcontrib>Hsu, Ping-I</creatorcontrib><creatorcontrib>Tseng, Hui-Hwa</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chou, Nan-Hua</au><au>Chen, Hui-Chun</au><au>Chou, Nan-Song</au><au>Hsu, Ping-I</au><au>Tseng, Hui-Hwa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of altered retinoblastoma protein inversely correlates with tumor invasion in gastric carcinoma</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2006-11-28</date><risdate>2006</risdate><volume>12</volume><issue>44</issue><spage>7188</spage><epage>7191</epage><pages>7188-7191</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM： To investigate the clinical and pathological significance of altered retinoblastoma （Rb） encoding protein （pRb） in gastric carcinoma.
METHODS： Expression of altered pRb was analyzed in 91 patients with gastric adenocarcinoma by immunohistochemistry. RESULTS： Sixty-five percent （59/91） of the tumors were positively stained and the staining in tumor nuclei of gastric carcinoma ranged 0%-90%. Moreover, strong expression of altered pRb was found in 35% （6/17）, 24% （5/21）, 17% （8/46） and 0% （0/7） of T1, T2, T3 and T4 gastric carcinomas, respectively. Altered pRb expression was inversely correlated with the depth of tumor invasion （P = 0.047）. Degree of immunoreactivity had no significant correlation with tumor grade, node metastasis and distant metastasis. In terms of prognostic significance, univariate analysis showed that poor differentiation [41 （66.1%） vs 34 （42.5%） P = 0.051], advanced tumor stage （P 〈 0.001） and weakly altered pRb expression [17 （80.5%） vs 58 （49.6%） P = 0.044] were associated with worse prognosis in these patients. However, multivariate analysis revealed that advanced tumor stage was the only independent poor prognostic factor （P 〈 0.001）.
CONCLUSION： The mutation of Rb gene is frequent in gastric carcinoma. The expression of altered pRb inversely correlates with tumor invasion and is not an independent prognostic marker in gastric adenocarcinoma.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Co., Limited</pub><pmid>17131485</pmid><doi>10.3748/wjg.v12.i44.7188</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma - diagnosis Adenocarcinoma - metabolism Adenocarcinoma - pathology Adult Aged Aged, 80 and over Female Gene Expression Regulation, Neoplastic Humans Male Middle Aged Mutation Neoplasm Invasiveness Prognosis Rapid Communication Retinoblastoma Protein - genetics Retinoblastoma Protein - metabolism Stomach Neoplasms - diagnosis Stomach Neoplasms - metabolism Stomach Neoplasms - pathology 眼癌 肿瘤细胞入侵 肿瘤细胞转移 胃癌 蛋白质 |
| title | Expression of altered retinoblastoma protein inversely correlates with tumor invasion in gastric carcinoma |
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