Effect of blocking IGF-Ⅰ receptor on growth of human hepatocellular carcinoma cells

AIM： To study the expression level and localization of insulin-like growth factor -Ⅰ receptor （IGF-IR） in HepG2 cells and Chang liver cells, and to observe the effect of anti-IGF-IR monoclonal antibody （αIR3） on the growth of HepG2 cells. METHODS： The expression of IGF-IR in HepG2 cells and Chang li...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2006-07, Vol.12 (25), p.3977-3982
Hauptverfasser:	Zhang, You-Cheng, Wang, Xiao-Peng, Zhang, Ling-Yi, Song, Ai-Lin, Kou, Zhi-Min, Li, Xu-Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - pharmacology Apoptosis - drug effects Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - ultrastructure Cell Cycle - drug effects Cell Line, Tumor Cell Proliferation - drug effects Hepatocytes - drug effects Hepatocytes - metabolism Hepatocytes - ultrastructure Humans Liver Cancer Liver Neoplasms - metabolism Liver Neoplasms - ultrastructure Receptor, IGF Type 1 - immunology Receptor, IGF Type 1 - metabolism 肝细胞癌肿瘤细胞胰岛素
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