Correlative studies on uPA mRNA and uPAR mRNA expression with vascular endothelial growth factor, microvessel density, progression and survival time of patients with gastric cancer
AIM： To investigate the correlations between the expression of urokinase-type plasminogen activator （uPA） mRNA, uPA receptor （uPAR） mRNA and vascular endothelial growth factor （VEGF） protein and clinicopathologic features, microvessel density （MVD） and survival time. METHODS： In situ hybridization a...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2006-07, Vol.12 (25), p.3970-3976 |
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| creator | Zhang, Li Zhao, Zhong-Sheng Ru, Guo-Qing Ma, Jie |
| description | AIM： To investigate the correlations between the expression of urokinase-type plasminogen activator （uPA） mRNA, uPA receptor （uPAR） mRNA and vascular endothelial growth factor （VEGF） protein and clinicopathologic features, microvessel density （MVD） and survival time.
METHODS： In situ hybridization and immuno-histochemistry techniques were used to study the expressions of uPA mRNA, uPAR mRNA, VEGF and CD34 protein in 105 gastric carcinoma specimens.
RESULTS： Expressions of uPA mRNA, uPAR mRNA and VEGF protein were observed in 61 （58.1%） cases, 70 （66.7%） cases and 67 （63.8%） cases, respectively. The uPA mRNA and uPAR mRNA positive expression rates in infiltrating-type cases （73.7%, 75.4%）, stage Ⅲ- Ⅳ （72.1%, 75.4%）, vessel invasion （63.2%, 69.9%）, lymphatic metastasis （67.1%, 74.4%） and distant metastasis （88.1%, 85.7%） were significantly higher than those of the expanding-type （χ^2 = 15.57, P = 0.001; χ^2 = 6.91, P = 0.046）, stage Ⅰ-Ⅱ （χ^2 = 19.22, P = 0.001; χ^2 = 16.75, P = 0.001）, non-vessel invasion （χ^2 = 11.92, P = 0.006; χ^2 = 14.15, P = 0.002）, non- lymphatic metastasis （χ^2 = 28.41, P = 0.001; χ^2 = 22.5, P = 0.005） and non-distant metastasis （χ^2 = 12.32, P = 0.004; χ^2 = 17.42, P = 0.002; χ^2 = 11.25, P = 0.012; χ^2 = 18.12, P = 0.002）.The VEGF positive expression rates in infiltrating-type cases （75.4%）, stage Ⅲ-Ⅳ （88.5%）, vessel invasion （82.9%）, lymphatic metastasis （84.3%） and distant metastasis （95.2%） were significantly higher than those of the expanding-type （χ^2 = 9.61, P = 0.021）,stage Ⅰ-Ⅱ （χ^2 = 16.66, P = 0.001）, non-vessel invasion （χ^2 = 29.38, P = 0.001）, non-lymphatic metastasis （χ^2 = 18.68, P = 0.005）, and non-distant metastasis （χ^2 = 22.72, P = 0.007; χ^2 = 21.62, P = 0.004）. The mean MVD in the specimens positive for the uPA mRNA, uPAR mRNA and VEGF protein was markedly higher than those with negative expression groups. Moreover, a positive relation between MVD and uPA mRNA （rs = 0.199, P = 0.042）, uPAR mRNA （rs = 0.278, P = 0.035）, and VEGF （rs = 0.398, P = 0.048） expressions was observed. The mean survival time in cases with positive uPA mRNA, uPAR mRNA and VEGF protein expression or MVD value ≥54.9 was significantly shorter than those in cases with negative expression or MVD value 〈 54.9.
CONCLUSION： uPA and uPAR expressions are correlated with enhanced VEGF-induced tumor angiogenesis and may play a role in invasion and nodal metastasis of gastric carcinoma, thereby serving as prognostic markers of gastric cancer. |
| doi_str_mv | 10.3748/wjg.v12.i25.3970 |
| format | Article |
| fullrecord | <record><control><sourceid>wanfang_jour_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4087704</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>22412254</cqvip_id><wanfj_id>wjg200625003</wanfj_id><sourcerecordid>wjg200625003</sourcerecordid><originalsourceid>FETCH-LOGICAL-c450t-c83267ee991e87985fa80f900fac9422061b2d7bb0446f436ec833b425e187313</originalsourceid><addsrcrecordid>eNpVUsuO0zAUjRCIKQN7VshCiNW0XD8SJ5uRqoqXNAI0grXlJDepS2J3bCdl_osPxFXLa2Vd3fOyfbLsOYUVl6J8c9j1q5mylWH5ilcSHmQLxmi1ZKWAh9mCAshlxZm8yJ6EsANgnOfscXZBi5KCFGyR_dw473HQ0cxIQpxag4E4S6YvazLefloTbdvjcHua8MfeYwgmIQ4mbsmsQzMN2hO0rYtbHIweSO_dIe063UTnr8hoGu_mxMKBtGiDifdXZO9d_1vpaBEmP5s5kaMZkbiO7FMktDGcfHodojcNabRt0D_NHnV6CPjsfF5m3969_br5sLz5_P7jZn2zbEQOcdmUnBUSsaoolrIq806X0FUAKVklGIOC1qyVdQ1CFJ3gBSYGrwXLkZaSU36ZXZ9091M9YtukPF4Pau_NqP29ctqo_zfWbFXvZiWglBJEEnh1Ejho22nbq52bvE2RVfo5BlCwHIAn2Ouzj3d3E4aoRhMaHAZt0U1BFWVe0QRPQDgB04uG4LH7k4WCOjbiqKtSI1RqhDo2IlFe_HuHv4RzBRLg5Vlz62x_Z1LKWjffOzOgYkxQxnLBfwH0i8Ji</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68591200</pqid></control><display><type>article</type><title>Correlative studies on uPA mRNA and uPAR mRNA expression with vascular endothelial growth factor, microvessel density, progression and survival time of patients with gastric cancer</title><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Zhang, Li ; Zhao, Zhong-Sheng ; Ru, Guo-Qing ; Ma, Jie</creator><creatorcontrib>Zhang, Li ; Zhao, Zhong-Sheng ; Ru, Guo-Qing ; Ma, Jie</creatorcontrib><description>AIM： To investigate the correlations between the expression of urokinase-type plasminogen activator （uPA） mRNA, uPA receptor （uPAR） mRNA and vascular endothelial growth factor （VEGF） protein and clinicopathologic features, microvessel density （MVD） and survival time.
METHODS： In situ hybridization and immuno-histochemistry techniques were used to study the expressions of uPA mRNA, uPAR mRNA, VEGF and CD34 protein in 105 gastric carcinoma specimens.
RESULTS： Expressions of uPA mRNA, uPAR mRNA and VEGF protein were observed in 61 （58.1%） cases, 70 （66.7%） cases and 67 （63.8%） cases, respectively. The uPA mRNA and uPAR mRNA positive expression rates in infiltrating-type cases （73.7%, 75.4%）, stage Ⅲ- Ⅳ （72.1%, 75.4%）, vessel invasion （63.2%, 69.9%）, lymphatic metastasis （67.1%, 74.4%） and distant metastasis （88.1%, 85.7%） were significantly higher than those of the expanding-type （χ^2 = 15.57, P = 0.001; χ^2 = 6.91, P = 0.046）, stage Ⅰ-Ⅱ （χ^2 = 19.22, P = 0.001; χ^2 = 16.75, P = 0.001）, non-vessel invasion （χ^2 = 11.92, P = 0.006; χ^2 = 14.15, P = 0.002）, non- lymphatic metastasis （χ^2 = 28.41, P = 0.001; χ^2 = 22.5, P = 0.005） and non-distant metastasis （χ^2 = 12.32, P = 0.004; χ^2 = 17.42, P = 0.002; χ^2 = 11.25, P = 0.012; χ^2 = 18.12, P = 0.002）.The VEGF positive expression rates in infiltrating-type cases （75.4%）, stage Ⅲ-Ⅳ （88.5%）, vessel invasion （82.9%）, lymphatic metastasis （84.3%） and distant metastasis （95.2%） were significantly higher than those of the expanding-type （χ^2 = 9.61, P = 0.021）,stage Ⅰ-Ⅱ （χ^2 = 16.66, P = 0.001）, non-vessel invasion （χ^2 = 29.38, P = 0.001）, non-lymphatic metastasis （χ^2 = 18.68, P = 0.005）, and non-distant metastasis （χ^2 = 22.72, P = 0.007; χ^2 = 21.62, P = 0.004）. The mean MVD in the specimens positive for the uPA mRNA, uPAR mRNA and VEGF protein was markedly higher than those with negative expression groups. Moreover, a positive relation between MVD and uPA mRNA （rs = 0.199, P = 0.042）, uPAR mRNA （rs = 0.278, P = 0.035）, and VEGF （rs = 0.398, P = 0.048） expressions was observed. The mean survival time in cases with positive uPA mRNA, uPAR mRNA and VEGF protein expression or MVD value ≥54.9 was significantly shorter than those in cases with negative expression or MVD value 〈 54.9.
CONCLUSION： uPA and uPAR expressions are correlated with enhanced VEGF-induced tumor angiogenesis and may play a role in invasion and nodal metastasis of gastric carcinoma, thereby serving as prognostic markers of gastric cancer.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v12.i25.3970</identifier><identifier>PMID: 16810742</identifier><language>eng</language><publisher>United States: Shaoxing University Medical College, Shaoxing 312000, Zhejiang Province, China%Department of Pathology, Zhejiang Provincial Hospital, Hangzhou 310014,Zhejiang Province, China</publisher><subject>Adenocarcinoma - metabolism ; Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adult ; Aged ; Disease Progression ; Female ; Gastric Cancer ; Gastric Mucosa - metabolism ; Humans ; Male ; Microcirculation - metabolism ; Microcirculation - pathology ; Middle Aged ; Neovascularization, Pathologic - metabolism ; Neovascularization, Pathologic - mortality ; Neovascularization, Pathologic - pathology ; Receptors, Cell Surface - metabolism ; Receptors, Urokinase Plasminogen Activator ; RNA, Messenger - metabolism ; Stomach - blood supply ; Stomach - pathology ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - mortality ; Stomach Neoplasms - pathology ; Survival Rate ; Urokinase-Type Plasminogen Activator - metabolism ; Vascular Endothelial Growth Factor A - metabolism ; 基因表达 ; 微血管密度 ; 血管内皮生长因子</subject><ispartof>World journal of gastroenterology : WJG, 2006-07, Vol.12 (25), p.3970-3976</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2006 Baishideng Publishing Group Co., Limited. All rights reserved. 2006</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-c83267ee991e87985fa80f900fac9422061b2d7bb0446f436ec833b425e187313</citedby><cites>FETCH-LOGICAL-c450t-c83267ee991e87985fa80f900fac9422061b2d7bb0446f436ec833b425e187313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087704/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087704/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16810742$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Li</creatorcontrib><creatorcontrib>Zhao, Zhong-Sheng</creatorcontrib><creatorcontrib>Ru, Guo-Qing</creatorcontrib><creatorcontrib>Ma, Jie</creatorcontrib><title>Correlative studies on uPA mRNA and uPAR mRNA expression with vascular endothelial growth factor, microvessel density, progression and survival time of patients with gastric cancer</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM： To investigate the correlations between the expression of urokinase-type plasminogen activator （uPA） mRNA, uPA receptor （uPAR） mRNA and vascular endothelial growth factor （VEGF） protein and clinicopathologic features, microvessel density （MVD） and survival time.
METHODS： In situ hybridization and immuno-histochemistry techniques were used to study the expressions of uPA mRNA, uPAR mRNA, VEGF and CD34 protein in 105 gastric carcinoma specimens.
RESULTS： Expressions of uPA mRNA, uPAR mRNA and VEGF protein were observed in 61 （58.1%） cases, 70 （66.7%） cases and 67 （63.8%） cases, respectively. The uPA mRNA and uPAR mRNA positive expression rates in infiltrating-type cases （73.7%, 75.4%）, stage Ⅲ- Ⅳ （72.1%, 75.4%）, vessel invasion （63.2%, 69.9%）, lymphatic metastasis （67.1%, 74.4%） and distant metastasis （88.1%, 85.7%） were significantly higher than those of the expanding-type （χ^2 = 15.57, P = 0.001; χ^2 = 6.91, P = 0.046）, stage Ⅰ-Ⅱ （χ^2 = 19.22, P = 0.001; χ^2 = 16.75, P = 0.001）, non-vessel invasion （χ^2 = 11.92, P = 0.006; χ^2 = 14.15, P = 0.002）, non- lymphatic metastasis （χ^2 = 28.41, P = 0.001; χ^2 = 22.5, P = 0.005） and non-distant metastasis （χ^2 = 12.32, P = 0.004; χ^2 = 17.42, P = 0.002; χ^2 = 11.25, P = 0.012; χ^2 = 18.12, P = 0.002）.The VEGF positive expression rates in infiltrating-type cases （75.4%）, stage Ⅲ-Ⅳ （88.5%）, vessel invasion （82.9%）, lymphatic metastasis （84.3%） and distant metastasis （95.2%） were significantly higher than those of the expanding-type （χ^2 = 9.61, P = 0.021）,stage Ⅰ-Ⅱ （χ^2 = 16.66, P = 0.001）, non-vessel invasion （χ^2 = 29.38, P = 0.001）, non-lymphatic metastasis （χ^2 = 18.68, P = 0.005）, and non-distant metastasis （χ^2 = 22.72, P = 0.007; χ^2 = 21.62, P = 0.004）. The mean MVD in the specimens positive for the uPA mRNA, uPAR mRNA and VEGF protein was markedly higher than those with negative expression groups. Moreover, a positive relation between MVD and uPA mRNA （rs = 0.199, P = 0.042）, uPAR mRNA （rs = 0.278, P = 0.035）, and VEGF （rs = 0.398, P = 0.048） expressions was observed. The mean survival time in cases with positive uPA mRNA, uPAR mRNA and VEGF protein expression or MVD value ≥54.9 was significantly shorter than those in cases with negative expression or MVD value 〈 54.9.
CONCLUSION： uPA and uPAR expressions are correlated with enhanced VEGF-induced tumor angiogenesis and may play a role in invasion and nodal metastasis of gastric carcinoma, thereby serving as prognostic markers of gastric cancer.</description><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Gastric Cancer</subject><subject>Gastric Mucosa - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Microcirculation - metabolism</subject><subject>Microcirculation - pathology</subject><subject>Middle Aged</subject><subject>Neovascularization, Pathologic - metabolism</subject><subject>Neovascularization, Pathologic - mortality</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Receptors, Urokinase Plasminogen Activator</subject><subject>RNA, Messenger - metabolism</subject><subject>Stomach - blood supply</subject><subject>Stomach - pathology</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - mortality</subject><subject>Stomach Neoplasms - pathology</subject><subject>Survival Rate</subject><subject>Urokinase-Type Plasminogen Activator - metabolism</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><subject>基因表达</subject><subject>微血管密度</subject><subject>血管内皮生长因子</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUsuO0zAUjRCIKQN7VshCiNW0XD8SJ5uRqoqXNAI0grXlJDepS2J3bCdl_osPxFXLa2Vd3fOyfbLsOYUVl6J8c9j1q5mylWH5ilcSHmQLxmi1ZKWAh9mCAshlxZm8yJ6EsANgnOfscXZBi5KCFGyR_dw473HQ0cxIQpxag4E4S6YvazLefloTbdvjcHua8MfeYwgmIQ4mbsmsQzMN2hO0rYtbHIweSO_dIe063UTnr8hoGu_mxMKBtGiDifdXZO9d_1vpaBEmP5s5kaMZkbiO7FMktDGcfHodojcNabRt0D_NHnV6CPjsfF5m3969_br5sLz5_P7jZn2zbEQOcdmUnBUSsaoolrIq806X0FUAKVklGIOC1qyVdQ1CFJ3gBSYGrwXLkZaSU36ZXZ9091M9YtukPF4Pau_NqP29ctqo_zfWbFXvZiWglBJEEnh1Ejho22nbq52bvE2RVfo5BlCwHIAn2Ouzj3d3E4aoRhMaHAZt0U1BFWVe0QRPQDgB04uG4LH7k4WCOjbiqKtSI1RqhDo2IlFe_HuHv4RzBRLg5Vlz62x_Z1LKWjffOzOgYkxQxnLBfwH0i8Ji</recordid><startdate>20060707</startdate><enddate>20060707</enddate><creator>Zhang, Li</creator><creator>Zhao, Zhong-Sheng</creator><creator>Ru, Guo-Qing</creator><creator>Ma, Jie</creator><general>Shaoxing University Medical College, Shaoxing 312000, Zhejiang Province, China%Department of Pathology, Zhejiang Provincial Hospital, Hangzhou 310014,Zhejiang Province, China</general><general>Department of Pathology, Wenzhou Medical College,Wenzhou 325000, Zhejiang Province, China</general><general>Baishideng Publishing Group Co., Limited</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20060707</creationdate><title>Correlative studies on uPA mRNA and uPAR mRNA expression with vascular endothelial growth factor, microvessel density, progression and survival time of patients with gastric cancer</title><author>Zhang, Li ; Zhao, Zhong-Sheng ; Ru, Guo-Qing ; Ma, Jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-c83267ee991e87985fa80f900fac9422061b2d7bb0446f436ec833b425e187313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Gastric Cancer</topic><topic>Gastric Mucosa - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Microcirculation - metabolism</topic><topic>Microcirculation - pathology</topic><topic>Middle Aged</topic><topic>Neovascularization, Pathologic - metabolism</topic><topic>Neovascularization, Pathologic - mortality</topic><topic>Neovascularization, Pathologic - pathology</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Receptors, Urokinase Plasminogen Activator</topic><topic>RNA, Messenger - metabolism</topic><topic>Stomach - blood supply</topic><topic>Stomach - pathology</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - mortality</topic><topic>Stomach Neoplasms - pathology</topic><topic>Survival Rate</topic><topic>Urokinase-Type Plasminogen Activator - metabolism</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><topic>基因表达</topic><topic>微血管密度</topic><topic>血管内皮生长因子</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Li</creatorcontrib><creatorcontrib>Zhao, Zhong-Sheng</creatorcontrib><creatorcontrib>Ru, Guo-Qing</creatorcontrib><creatorcontrib>Ma, Jie</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Li</au><au>Zhao, Zhong-Sheng</au><au>Ru, Guo-Qing</au><au>Ma, Jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlative studies on uPA mRNA and uPAR mRNA expression with vascular endothelial growth factor, microvessel density, progression and survival time of patients with gastric cancer</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2006-07-07</date><risdate>2006</risdate><volume>12</volume><issue>25</issue><spage>3970</spage><epage>3976</epage><pages>3970-3976</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM： To investigate the correlations between the expression of urokinase-type plasminogen activator （uPA） mRNA, uPA receptor （uPAR） mRNA and vascular endothelial growth factor （VEGF） protein and clinicopathologic features, microvessel density （MVD） and survival time.
METHODS： In situ hybridization and immuno-histochemistry techniques were used to study the expressions of uPA mRNA, uPAR mRNA, VEGF and CD34 protein in 105 gastric carcinoma specimens.
RESULTS： Expressions of uPA mRNA, uPAR mRNA and VEGF protein were observed in 61 （58.1%） cases, 70 （66.7%） cases and 67 （63.8%） cases, respectively. The uPA mRNA and uPAR mRNA positive expression rates in infiltrating-type cases （73.7%, 75.4%）, stage Ⅲ- Ⅳ （72.1%, 75.4%）, vessel invasion （63.2%, 69.9%）, lymphatic metastasis （67.1%, 74.4%） and distant metastasis （88.1%, 85.7%） were significantly higher than those of the expanding-type （χ^2 = 15.57, P = 0.001; χ^2 = 6.91, P = 0.046）, stage Ⅰ-Ⅱ （χ^2 = 19.22, P = 0.001; χ^2 = 16.75, P = 0.001）, non-vessel invasion （χ^2 = 11.92, P = 0.006; χ^2 = 14.15, P = 0.002）, non- lymphatic metastasis （χ^2 = 28.41, P = 0.001; χ^2 = 22.5, P = 0.005） and non-distant metastasis （χ^2 = 12.32, P = 0.004; χ^2 = 17.42, P = 0.002; χ^2 = 11.25, P = 0.012; χ^2 = 18.12, P = 0.002）.The VEGF positive expression rates in infiltrating-type cases （75.4%）, stage Ⅲ-Ⅳ （88.5%）, vessel invasion （82.9%）, lymphatic metastasis （84.3%） and distant metastasis （95.2%） were significantly higher than those of the expanding-type （χ^2 = 9.61, P = 0.021）,stage Ⅰ-Ⅱ （χ^2 = 16.66, P = 0.001）, non-vessel invasion （χ^2 = 29.38, P = 0.001）, non-lymphatic metastasis （χ^2 = 18.68, P = 0.005）, and non-distant metastasis （χ^2 = 22.72, P = 0.007; χ^2 = 21.62, P = 0.004）. The mean MVD in the specimens positive for the uPA mRNA, uPAR mRNA and VEGF protein was markedly higher than those with negative expression groups. Moreover, a positive relation between MVD and uPA mRNA （rs = 0.199, P = 0.042）, uPAR mRNA （rs = 0.278, P = 0.035）, and VEGF （rs = 0.398, P = 0.048） expressions was observed. The mean survival time in cases with positive uPA mRNA, uPAR mRNA and VEGF protein expression or MVD value ≥54.9 was significantly shorter than those in cases with negative expression or MVD value 〈 54.9.
CONCLUSION： uPA and uPAR expressions are correlated with enhanced VEGF-induced tumor angiogenesis and may play a role in invasion and nodal metastasis of gastric carcinoma, thereby serving as prognostic markers of gastric cancer.</abstract><cop>United States</cop><pub>Shaoxing University Medical College, Shaoxing 312000, Zhejiang Province, China%Department of Pathology, Zhejiang Provincial Hospital, Hangzhou 310014,Zhejiang Province, China</pub><pmid>16810742</pmid><doi>10.3748/wjg.v12.i25.3970</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | World journal of gastroenterology : WJG, 2006-07, Vol.12 (25), p.3970-3976 |
| issn | 1007-9327 2219-2840 |
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| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4087704 |
| source | MEDLINE; PubMed Central; Alma/SFX Local Collection |
| subjects | Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma - pathology Adult Aged Disease Progression Female Gastric Cancer Gastric Mucosa - metabolism Humans Male Microcirculation - metabolism Microcirculation - pathology Middle Aged Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - mortality Neovascularization, Pathologic - pathology Receptors, Cell Surface - metabolism Receptors, Urokinase Plasminogen Activator RNA, Messenger - metabolism Stomach - blood supply Stomach - pathology Stomach Neoplasms - metabolism Stomach Neoplasms - mortality Stomach Neoplasms - pathology Survival Rate Urokinase-Type Plasminogen Activator - metabolism Vascular Endothelial Growth Factor A - metabolism 基因表达 微血管密度 血管内皮生长因子 |
| title | Correlative studies on uPA mRNA and uPAR mRNA expression with vascular endothelial growth factor, microvessel density, progression and survival time of patients with gastric cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T03%3A25%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wanfang_jour_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Correlative%20studies%20on%20uPA%20mRNA%20and%20uPAR%20mRNA%20expression%20with%20vascular%20endothelial%20growth%20factor,%20microvessel%20density,%20progression%20and%20survival%20time%20of%20patients%20with%20gastric%20cancer&rft.jtitle=World%20journal%20of%20gastroenterology%20:%20WJG&rft.au=Zhang,%20Li&rft.date=2006-07-07&rft.volume=12&rft.issue=25&rft.spage=3970&rft.epage=3976&rft.pages=3970-3976&rft.issn=1007-9327&rft.eissn=2219-2840&rft_id=info:doi/10.3748/wjg.v12.i25.3970&rft_dat=%3Cwanfang_jour_pubme%3Ewjg200625003%3C/wanfang_jour_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68591200&rft_id=info:pmid/16810742&rft_cqvip_id=22412254&rft_wanfj_id=wjg200625003&rfr_iscdi=true |