Interleukin-2 gene-encoded stromal cells inhibit the growth of metastatic cholangiocarcinomas
AIM: To demonstrate bone marrow stromal cells (BMSCs) can be used as an attractive target for genetic modification in the treatment of malignant diseases. METHODS: Using a hamster model of biliary cancer, we investigated the therapeutic effects of interleukin-2 (IL-2) gene-modified BHSCs. Syrian gol...
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Veröffentlicht in: | World journal of gastroenterology : WJG 2006-03, Vol.12 (12), p.1889-1894 |
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container_title | World journal of gastroenterology : WJG |
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creator | Kim, Myung-Hwan Lee, Sang Soo Lee, Sung Koo Lee, Seung-Gyu Suh, Chul-Won Gong, Gyung-Yub Park, Jung-Sun Kim, Young-Hoon Kim, Sang-Hee |
description | AIM: To demonstrate bone marrow stromal cells (BMSCs) can be used as an attractive target for genetic modification in the treatment of malignant diseases.
METHODS: Using a hamster model of biliary cancer, we investigated the therapeutic effects of interleukin-2 (IL-2) gene-modified BHSCs. Syrian golden hamsters were injected via the femoral vein with 5×10^5 cells of the KIGB-5 biliary cancer cell line (n=20). One week later, the hamsters were injected intraperitoneally with BMSCs containing Ad/hIL-2 and Ad/△E1, unmodified BHSCs, or RPHI only (control) and observed for 12 wk (n=5/each group).
RESULTS: All hamsters treated with BMSCs containing Ad/hIL-2 survived with no evidence of the disease during this period. In contrast, hamsters in the other three groups showed disseminated metastases involving the lungs as eady as 4 wk.
CONCLUSION: Ad/IL-2 therapy is effective in the treatment of biliary cancer. |
doi_str_mv | 10.3748/wjg.v12.i12.1889 |
format | Article |
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METHODS: Using a hamster model of biliary cancer, we investigated the therapeutic effects of interleukin-2 (IL-2) gene-modified BHSCs. Syrian golden hamsters were injected via the femoral vein with 5×10^5 cells of the KIGB-5 biliary cancer cell line (n=20). One week later, the hamsters were injected intraperitoneally with BMSCs containing Ad/hIL-2 and Ad/△E1, unmodified BHSCs, or RPHI only (control) and observed for 12 wk (n=5/each group).
RESULTS: All hamsters treated with BMSCs containing Ad/hIL-2 survived with no evidence of the disease during this period. In contrast, hamsters in the other three groups showed disseminated metastases involving the lungs as eady as 4 wk.
CONCLUSION: Ad/IL-2 therapy is effective in the treatment of biliary cancer.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v12.i12.1889</identifier><identifier>PMID: 16609995</identifier><language>eng</language><publisher>United States: Department of Gastroenterology, University of Ulsan College of Medicine,Asan Medical Center, Seoul, Korea%Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea%Department of Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea%Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea%Asan Institute for Life Sciences, Seoul, Korea</publisher><subject>Animals ; Basic Research ; Bile Duct Neoplasms - pathology ; Bile Duct Neoplasms - therapy ; Bone Marrow Cells - physiology ; Bone Marrow Transplantation ; Cell Line, Tumor ; Cholangiocarcinoma - secondary ; Cholangiocarcinoma - therapy ; Cricetinae ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Interleukin-2 - genetics ; Lung Neoplasms - secondary ; Mesocricetus ; Stromal Cells - physiology ; Transduction, Genetic ; Xenograft Model Antitumor Assays ; 基因编码 ; 基质细胞 ; 白细胞介素-2 ; 胆管癌</subject><ispartof>World journal of gastroenterology : WJG, 2006-03, Vol.12 (12), p.1889-1894</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2006 Baishideng Publishing Group Co., Limited. All rights reserved. 2006</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-e466dc462449213d724d821c2d31e11d96d9ddc429bc312c094755b5c76f8c893</citedby><cites>FETCH-LOGICAL-c450t-e466dc462449213d724d821c2d31e11d96d9ddc429bc312c094755b5c76f8c893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087514/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087514/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16609995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Myung-Hwan</creatorcontrib><creatorcontrib>Lee, Sang Soo</creatorcontrib><creatorcontrib>Lee, Sung Koo</creatorcontrib><creatorcontrib>Lee, Seung-Gyu</creatorcontrib><creatorcontrib>Suh, Chul-Won</creatorcontrib><creatorcontrib>Gong, Gyung-Yub</creatorcontrib><creatorcontrib>Park, Jung-Sun</creatorcontrib><creatorcontrib>Kim, Young-Hoon</creatorcontrib><creatorcontrib>Kim, Sang-Hee</creatorcontrib><title>Interleukin-2 gene-encoded stromal cells inhibit the growth of metastatic cholangiocarcinomas</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM: To demonstrate bone marrow stromal cells (BMSCs) can be used as an attractive target for genetic modification in the treatment of malignant diseases.
METHODS: Using a hamster model of biliary cancer, we investigated the therapeutic effects of interleukin-2 (IL-2) gene-modified BHSCs. Syrian golden hamsters were injected via the femoral vein with 5×10^5 cells of the KIGB-5 biliary cancer cell line (n=20). One week later, the hamsters were injected intraperitoneally with BMSCs containing Ad/hIL-2 and Ad/△E1, unmodified BHSCs, or RPHI only (control) and observed for 12 wk (n=5/each group).
RESULTS: All hamsters treated with BMSCs containing Ad/hIL-2 survived with no evidence of the disease during this period. In contrast, hamsters in the other three groups showed disseminated metastases involving the lungs as eady as 4 wk.
CONCLUSION: Ad/IL-2 therapy is effective in the treatment of biliary cancer.</description><subject>Animals</subject><subject>Basic Research</subject><subject>Bile Duct Neoplasms - pathology</subject><subject>Bile Duct Neoplasms - therapy</subject><subject>Bone Marrow Cells - physiology</subject><subject>Bone Marrow Transplantation</subject><subject>Cell Line, Tumor</subject><subject>Cholangiocarcinoma - secondary</subject><subject>Cholangiocarcinoma - therapy</subject><subject>Cricetinae</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Interleukin-2 - genetics</subject><subject>Lung Neoplasms - secondary</subject><subject>Mesocricetus</subject><subject>Stromal Cells - physiology</subject><subject>Transduction, Genetic</subject><subject>Xenograft Model Antitumor Assays</subject><subject>基因编码</subject><subject>基质细胞</subject><subject>白细胞介素-2</subject><subject>胆管癌</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUuPFCEUhYnROO3o3pUhxrirlldBsTGZTHxMMokbXRpCAVVFTxXMADUd_71UuuNjASw497vn3gPAa4z2VLDuw_Ew7h8x2ft6cNfJJ2BHCJYN6Rh6CnYYIdFISsQFeJHzASFCaUuegwvMOZJStjvw8yYUl2a33vnQEDi64BoXTLTOwlxSXPQMjZvnDH2YfO8LLJODY4rHMsE4wMUVnYsu3kAzxVmH0Uejk_GhluaX4Nmg5-xend9L8OPzp-_XX5vbb19urq9uG8NaVBrHOLeGccKYJJhaQZjtCDbEUuwwtpJbaauAyN5QTAySTLRt3xrBh850kl6Cjyfu_dovzhoXStKzuk9-0emXitqr_3-Cn9QYHxVDnWgxq4B3J8BRh6EOoQ5xTaFaVnXFBCGO67X1eX_uk-LD6nJRi8_benRwcc2Ki66VXG48dBKaFHNObvjjBSO1RbdxVY1O1ejUFl0tefPvDH8LzllVwdszc4phfPDVZa_N3eBnpwgWiGKG6W_SJqLB</recordid><startdate>20060328</startdate><enddate>20060328</enddate><creator>Kim, Myung-Hwan</creator><creator>Lee, Sang Soo</creator><creator>Lee, Sung Koo</creator><creator>Lee, Seung-Gyu</creator><creator>Suh, Chul-Won</creator><creator>Gong, Gyung-Yub</creator><creator>Park, Jung-Sun</creator><creator>Kim, Young-Hoon</creator><creator>Kim, Sang-Hee</creator><general>Department of Gastroenterology, University of Ulsan College of Medicine,Asan Medical Center, Seoul, Korea%Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea%Department of Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea%Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea%Asan Institute for Life Sciences, Seoul, Korea</general><general>Baishideng Publishing Group Co., Limited</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20060328</creationdate><title>Interleukin-2 gene-encoded stromal cells inhibit the growth of metastatic cholangiocarcinomas</title><author>Kim, Myung-Hwan ; Lee, Sang Soo ; Lee, Sung Koo ; Lee, Seung-Gyu ; Suh, Chul-Won ; Gong, Gyung-Yub ; Park, Jung-Sun ; Kim, Young-Hoon ; Kim, Sang-Hee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-e466dc462449213d724d821c2d31e11d96d9ddc429bc312c094755b5c76f8c893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Basic Research</topic><topic>Bile Duct Neoplasms - pathology</topic><topic>Bile Duct Neoplasms - therapy</topic><topic>Bone Marrow Cells - physiology</topic><topic>Bone Marrow Transplantation</topic><topic>Cell Line, Tumor</topic><topic>Cholangiocarcinoma - secondary</topic><topic>Cholangiocarcinoma - therapy</topic><topic>Cricetinae</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Interleukin-2 - genetics</topic><topic>Lung Neoplasms - secondary</topic><topic>Mesocricetus</topic><topic>Stromal Cells - physiology</topic><topic>Transduction, Genetic</topic><topic>Xenograft Model Antitumor Assays</topic><topic>基因编码</topic><topic>基质细胞</topic><topic>白细胞介素-2</topic><topic>胆管癌</topic><toplevel>online_resources</toplevel><creatorcontrib>Kim, Myung-Hwan</creatorcontrib><creatorcontrib>Lee, Sang Soo</creatorcontrib><creatorcontrib>Lee, Sung Koo</creatorcontrib><creatorcontrib>Lee, Seung-Gyu</creatorcontrib><creatorcontrib>Suh, Chul-Won</creatorcontrib><creatorcontrib>Gong, Gyung-Yub</creatorcontrib><creatorcontrib>Park, Jung-Sun</creatorcontrib><creatorcontrib>Kim, Young-Hoon</creatorcontrib><creatorcontrib>Kim, Sang-Hee</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Myung-Hwan</au><au>Lee, Sang Soo</au><au>Lee, Sung Koo</au><au>Lee, Seung-Gyu</au><au>Suh, Chul-Won</au><au>Gong, Gyung-Yub</au><au>Park, Jung-Sun</au><au>Kim, Young-Hoon</au><au>Kim, Sang-Hee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-2 gene-encoded stromal cells inhibit the growth of metastatic cholangiocarcinomas</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2006-03-28</date><risdate>2006</risdate><volume>12</volume><issue>12</issue><spage>1889</spage><epage>1894</epage><pages>1889-1894</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM: To demonstrate bone marrow stromal cells (BMSCs) can be used as an attractive target for genetic modification in the treatment of malignant diseases.
METHODS: Using a hamster model of biliary cancer, we investigated the therapeutic effects of interleukin-2 (IL-2) gene-modified BHSCs. Syrian golden hamsters were injected via the femoral vein with 5×10^5 cells of the KIGB-5 biliary cancer cell line (n=20). One week later, the hamsters were injected intraperitoneally with BMSCs containing Ad/hIL-2 and Ad/△E1, unmodified BHSCs, or RPHI only (control) and observed for 12 wk (n=5/each group).
RESULTS: All hamsters treated with BMSCs containing Ad/hIL-2 survived with no evidence of the disease during this period. In contrast, hamsters in the other three groups showed disseminated metastases involving the lungs as eady as 4 wk.
CONCLUSION: Ad/IL-2 therapy is effective in the treatment of biliary cancer.</abstract><cop>United States</cop><pub>Department of Gastroenterology, University of Ulsan College of Medicine,Asan Medical Center, Seoul, Korea%Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea%Department of Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea%Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea%Asan Institute for Life Sciences, Seoul, Korea</pub><pmid>16609995</pmid><doi>10.3748/wjg.v12.i12.1889</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; PubMed Central; Alma/SFX Local Collection |
subjects | Animals Basic Research Bile Duct Neoplasms - pathology Bile Duct Neoplasms - therapy Bone Marrow Cells - physiology Bone Marrow Transplantation Cell Line, Tumor Cholangiocarcinoma - secondary Cholangiocarcinoma - therapy Cricetinae Female Gene Expression Regulation, Neoplastic Humans Interleukin-2 - genetics Lung Neoplasms - secondary Mesocricetus Stromal Cells - physiology Transduction, Genetic Xenograft Model Antitumor Assays 基因编码 基质细胞 白细胞介素-2 胆管癌 |
title | Interleukin-2 gene-encoded stromal cells inhibit the growth of metastatic cholangiocarcinomas |
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