Poststroke Neuropsychiatric Symptoms : Relationships with IL-17 and Oxidative Stress
Stroke variably activates interleukin- (IL-) 17 expression, reduces regulatory T cells, and induces oxidative stress, which may support neurodegeneration. Ischemic stroke patients were screened for depressive symptoms (Center for Epidemiological Studies Depression (CES-D)) and cognitive status (Mini...
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| Veröffentlicht in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-6 |
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| description | Stroke variably activates interleukin- (IL-) 17 expression, reduces regulatory T cells, and induces oxidative stress, which may support neurodegeneration. Ischemic stroke patients were screened for depressive symptoms (Center for Epidemiological Studies Depression (CES-D)) and cognitive status (Mini Mental State Examination). Proinflammatory cytokines (IL-17, IL-23, and interferon- [IFN-] γ), anti-inflammatory cytokine IL-10, and lipid hydroperoxide (LPH), a measure of oxidative stress, were assayed from fasting serum. Of 47 subjects (age 71.8 ± 14.4 years, 36% female), 19 had depressive symptoms (CES-D ≥ 16), which was associated with poorer cognitive status (F1,46=8.44, P=0.006). IL-17 concentrations did not differ between subjects with and without depressive symptoms (F1,46=8.44, P=0.572); however, IL-17 was associated with poorer cognitive status in subjects with depressive symptoms (F1,46=9.29, P=0.004). In those subjects with depressive symptoms, IL-17 was associated with higher LPH (ρ=0.518, P=0.023) and lower IL-10 (ρ=-0.484, P=0.036), but not in those without. In conclusion, poststroke depressive symptoms may be associated with cognitive vulnerability to IL-17 related pathways, involving an imbalance between proinflammatory and anti-inflammatory activity and increased oxidative stress. |
| doi_str_mv | 10.1155/2014/245210 |
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H. ; Swardfager, W. ; Lanctôt, Krista L. ; Black, S. E. ; Khan, M. M. ; Andreazza, A. C.</creator><contributor>Tan, Eng-King</contributor><creatorcontrib>Herrmann, Nathan ; Swartz, R. H. ; Swardfager, W. ; Lanctôt, Krista L. ; Black, S. E. ; Khan, M. M. ; Andreazza, A. C. ; Tan, Eng-King</creatorcontrib><description>Stroke variably activates interleukin- (IL-) 17 expression, reduces regulatory T cells, and induces oxidative stress, which may support neurodegeneration. Ischemic stroke patients were screened for depressive symptoms (Center for Epidemiological Studies Depression (CES-D)) and cognitive status (Mini Mental State Examination). Proinflammatory cytokines (IL-17, IL-23, and interferon- [IFN-] γ), anti-inflammatory cytokine IL-10, and lipid hydroperoxide (LPH), a measure of oxidative stress, were assayed from fasting serum. Of 47 subjects (age 71.8 ± 14.4 years, 36% female), 19 had depressive symptoms (CES-D ≥ 16), which was associated with poorer cognitive status (F1,46=8.44, P=0.006). IL-17 concentrations did not differ between subjects with and without depressive symptoms (F1,46=8.44, P=0.572); however, IL-17 was associated with poorer cognitive status in subjects with depressive symptoms (F1,46=9.29, P=0.004). In those subjects with depressive symptoms, IL-17 was associated with higher LPH (ρ=0.518, P=0.023) and lower IL-10 (ρ=-0.484, P=0.036), but not in those without. In conclusion, poststroke depressive symptoms may be associated with cognitive vulnerability to IL-17 related pathways, involving an imbalance between proinflammatory and anti-inflammatory activity and increased oxidative stress.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/245210</identifier><identifier>PMID: 25054133</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Aged ; Aged, 80 and over ; Animal cognition ; Behavior ; Biomedical research ; Cognition disorders ; Cognition Disorders - complications ; Cognitive ability ; Cross-Sectional Studies ; Cytokines ; Cytokines - blood ; Depression - complications ; Depression, Mental ; Female ; Health aspects ; Health sciences ; Humans ; Inflammation ; Interleukin-17 - blood ; Interleukins ; Lipid Peroxides - blood ; Lymphocytes ; Male ; Mental Disorders - complications ; Middle Aged ; Nervous System Diseases - complications ; Neurodegeneration ; Older people ; Oxidative Stress ; Proteins ; Psychiatrists ; Stroke ; Stroke (Disease) ; Stroke - complications ; Stroke - physiopathology ; Studies</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-6</ispartof><rights>Copyright © 2014 W. Swardfager et al.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 W. Swardfager et al. W. Swardfager et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 W. Swardfager et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-953cba1fb39acab163cae0c68861fe087f208d57ca757232b2d73a93a532c2533</citedby><cites>FETCH-LOGICAL-c527t-953cba1fb39acab163cae0c68861fe087f208d57ca757232b2d73a93a532c2533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087285/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087285/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25054133$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Tan, Eng-King</contributor><creatorcontrib>Herrmann, Nathan</creatorcontrib><creatorcontrib>Swartz, R. H.</creatorcontrib><creatorcontrib>Swardfager, W.</creatorcontrib><creatorcontrib>Lanctôt, Krista L.</creatorcontrib><creatorcontrib>Black, S. E.</creatorcontrib><creatorcontrib>Khan, M. M.</creatorcontrib><creatorcontrib>Andreazza, A. C.</creatorcontrib><title>Poststroke Neuropsychiatric Symptoms : Relationships with IL-17 and Oxidative Stress</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Stroke variably activates interleukin- (IL-) 17 expression, reduces regulatory T cells, and induces oxidative stress, which may support neurodegeneration. Ischemic stroke patients were screened for depressive symptoms (Center for Epidemiological Studies Depression (CES-D)) and cognitive status (Mini Mental State Examination). Proinflammatory cytokines (IL-17, IL-23, and interferon- [IFN-] γ), anti-inflammatory cytokine IL-10, and lipid hydroperoxide (LPH), a measure of oxidative stress, were assayed from fasting serum. Of 47 subjects (age 71.8 ± 14.4 years, 36% female), 19 had depressive symptoms (CES-D ≥ 16), which was associated with poorer cognitive status (F1,46=8.44, P=0.006). IL-17 concentrations did not differ between subjects with and without depressive symptoms (F1,46=8.44, P=0.572); however, IL-17 was associated with poorer cognitive status in subjects with depressive symptoms (F1,46=9.29, P=0.004). In those subjects with depressive symptoms, IL-17 was associated with higher LPH (ρ=0.518, P=0.023) and lower IL-10 (ρ=-0.484, P=0.036), but not in those without. 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H.</au><au>Swardfager, W.</au><au>Lanctôt, Krista L.</au><au>Black, S. E.</au><au>Khan, M. M.</au><au>Andreazza, A. C.</au><au>Tan, Eng-King</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Poststroke Neuropsychiatric Symptoms : Relationships with IL-17 and Oxidative Stress</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2014</volume><issue>2014</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Stroke variably activates interleukin- (IL-) 17 expression, reduces regulatory T cells, and induces oxidative stress, which may support neurodegeneration. Ischemic stroke patients were screened for depressive symptoms (Center for Epidemiological Studies Depression (CES-D)) and cognitive status (Mini Mental State Examination). Proinflammatory cytokines (IL-17, IL-23, and interferon- [IFN-] γ), anti-inflammatory cytokine IL-10, and lipid hydroperoxide (LPH), a measure of oxidative stress, were assayed from fasting serum. Of 47 subjects (age 71.8 ± 14.4 years, 36% female), 19 had depressive symptoms (CES-D ≥ 16), which was associated with poorer cognitive status (F1,46=8.44, P=0.006). IL-17 concentrations did not differ between subjects with and without depressive symptoms (F1,46=8.44, P=0.572); however, IL-17 was associated with poorer cognitive status in subjects with depressive symptoms (F1,46=9.29, P=0.004). In those subjects with depressive symptoms, IL-17 was associated with higher LPH (ρ=0.518, P=0.023) and lower IL-10 (ρ=-0.484, P=0.036), but not in those without. In conclusion, poststroke depressive symptoms may be associated with cognitive vulnerability to IL-17 related pathways, involving an imbalance between proinflammatory and anti-inflammatory activity and increased oxidative stress.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>25054133</pmid><doi>10.1155/2014/245210</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Animal cognition Behavior Biomedical research Cognition disorders Cognition Disorders - complications Cognitive ability Cross-Sectional Studies Cytokines Cytokines - blood Depression - complications Depression, Mental Female Health aspects Health sciences Humans Inflammation Interleukin-17 - blood Interleukins Lipid Peroxides - blood Lymphocytes Male Mental Disorders - complications Middle Aged Nervous System Diseases - complications Neurodegeneration Older people Oxidative Stress Proteins Psychiatrists Stroke Stroke (Disease) Stroke - complications Stroke - physiopathology Studies |
| title | Poststroke Neuropsychiatric Symptoms : Relationships with IL-17 and Oxidative Stress |
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