Telmisartan protects central neurons against nutrient deprivation-induced apoptosis in vitro through activation of PPARγ and the Akt/GSK-3β pathway

Aim： To determine whether angiotensin II receptor blockers （ARBs） could protect central neurons against nutrient deprivation-induced apoptosis in vitro and to elucidate the underlying mechanisms. Methods： Primary rat cerebellar granule cells （CGCs） underwent B27 （a serum substitute） deprivation for...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Acta pharmacologica Sinica 2014-06, Vol.35 (6), p.727-737
Hauptverfasser:	Pang, Tao, Sun, Li-xin, Wang, Tao, Jiang, Zhen-zhou, Liao, Hong, Zhang, Lu-yong
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT Angiotensin II Type 1 Receptor Blockers - pharmacology Animals Apoptosis - drug effects Benzimidazoles - pharmacology Benzoates - pharmacology Biomedical and Life Sciences Biomedicine Cells, Cultured Cerebellum - cytology Female Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Immunology Internal Medicine Male Medical Microbiology Neurons - cytology Neurons - drug effects Neurons - metabolism Neuroprotective Agents - pharmacology Original original-article Pharmacology/Toxicology PPAR PPAR gamma - metabolism Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Signal Transduction - drug effects Vaccine 体外替米沙坦神经细胞细胞凋亡营养缺乏诱导
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!