The Role of Complement in Age-Related Macular Degeneration: Heparan Sulphate, a ZIP Code for Complement Factor H?

Age-related macular degeneration (AMD) is the leading cause of blindness in developed nations and has been associated with complement dysregulation in the central retina. The Y402H polymorphism in the complement regulatory protein factor H (CFH) can confer a >5-fold increased risk of developing A...

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Veröffentlicht in:	Journal of innate immunity 2014-01, Vol.6 (4), p.407-416
Hauptverfasser:	Langford-Smith, Alex, Keenan, Tiarnan D.L., Clark, Simon J., Bishop, Paul N., Day, Anthony J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bruch Membrane - metabolism Complement Activation - genetics Complement Factor H - genetics Complement Factor H - immunology Genetic Predisposition to Disease Heparitin Sulfate - metabolism Humans Macular Degeneration - immunology Polymorphism, Genetic Protein Binding - genetics Protein Interaction Domains and Motifs - genetics Retina - immunology Retina - pathology Review
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