Hypoxia Promotes Progesterone Synthesis During Luteinization in Bovine Granulosa Cells

To determine whether hypoxia has an effect on luteinization, we examined the influence of hypoxia on a model of bovine luteinizing and non-luteinizing granulosa cell culture. The granulosa cells were obtained from small antral follicles (≤ 6 mm in diameter). To induce luteinization, the cells were t...

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Veröffentlicht in:	Journal of Reproduction and Development 2014, Vol.60(3), pp.194-201
Hauptverfasser:	FADHILLAH, YOSHIOKA, Shin, NISHIMURA, Ryo, OKUDA, Kiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxysteroid Dehydrogenases - genetics 3-Hydroxysteroid Dehydrogenases - metabolism Animals Cattle Cells, Cultured Cholesterol Side-Chain Cleavage Enzyme - genetics Cholesterol Side-Chain Cleavage Enzyme - metabolism Dose-Response Relationship, Drug Female Gene Expression - drug effects Granulosa cells Granulosa Cells - drug effects Granulosa Cells - metabolism Hypoxia Hypoxia - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Luteinization Luteinization - drug effects Luteinization - metabolism Original Oxygen - pharmacology Phosphoproteins - genetics Phosphoproteins - metabolism Progesterone Progesterone - biosynthesis
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