Safety and antitumor activity of recombinant soluble Apo2 ligand

TNF and Fas ligand induce apoptosis in tumor cells; however, their severe toxicity toward normal tissues hampers their application to cancer therapy. Apo2 ligand (Apo2L, or TRAIL) is a related molecule that triggers tumor cell apoptosis. Apo2L mRNA is expressed in many tissues, suggesting that the l...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of clinical investigation 1999-07, Vol.104 (2), p.155-162
Hauptverfasser:	Ashkenazi, A, Pai, R C, Fong, S, Leung, S, Lawrence, D A, Marsters, S A, Blackie, C, Chang, L, McMurtrey, A E, Hebert, A, DeForge, L, Koumenis, I L, Lewis, D, Harris, L, Bussiere, J, Koeppen, H, Shahrokh, Z, Schwall, R H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis - drug effects Apoptosis Regulatory Proteins Fluorouracil - pharmacology Humans Ligands Macaca fascicularis Membrane Glycoproteins - pharmacology Membrane Glycoproteins - toxicity Mice Mice, Nude Neoplasms, Experimental - drug therapy NF-kappa B - metabolism Papio Recombinant Proteins - pharmacology TNF-Related Apoptosis-Inducing Ligand Tumor Cells, Cultured Tumor Necrosis Factor-alpha - pharmacology Tumor Necrosis Factor-alpha - toxicity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!