Putting CENP-A in its place
The centromere is the chromosomal region that directs kinetochore assembly during mitosis in order to facilitate the faithful segregation of sister chromatids. The location of the human centromere is epigenetically specified. The presence of nucleosomes that contain the histone H3 variant, CENP-A, a...
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2013-02, Vol.70 (3), p.387-406 |
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| creator | Stellfox, Madison E Bailey, Aaron O Foltz, Daniel R |
| description | The centromere is the chromosomal region that directs kinetochore assembly during mitosis in order to facilitate the faithful segregation of sister chromatids. The location of the human centromere is epigenetically specified. The presence of nucleosomes that contain the histone H3 variant, CENP-A, are thought to be the epigenetic mark that indicates active centromeres. Maintenance of centromeric identity requires the deposition of new CENP-A nucleosomes with each cell cycle. During S-phase, existing CENP-A nucleosomes are divided among the daughter chromosomes, while new CENP-A nucleosomes are deposited during early G1. The specific assembly of CENP-A nucleosomes at centromeres requires the Mis18 complex, which recruits the CENP-A assembly factor, HJURP. We will review the unique features of centromeric chromatin as well as the mechanism of CENP-A nucleosome deposition. We will also highlight a few recent discoveries that begin to elucidate the factors that temporally and spatially control CENP-A deposition. |
| doi_str_mv | 10.1007/s00018-012-1048-8 |
| format | Article |
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The location of the human centromere is epigenetically specified. The presence of nucleosomes that contain the histone H3 variant, CENP-A, are thought to be the epigenetic mark that indicates active centromeres. Maintenance of centromeric identity requires the deposition of new CENP-A nucleosomes with each cell cycle. During S-phase, existing CENP-A nucleosomes are divided among the daughter chromosomes, while new CENP-A nucleosomes are deposited during early G1. The specific assembly of CENP-A nucleosomes at centromeres requires the Mis18 complex, which recruits the CENP-A assembly factor, HJURP. We will review the unique features of centromeric chromatin as well as the mechanism of CENP-A nucleosome deposition. We will also highlight a few recent discoveries that begin to elucidate the factors that temporally and spatially control CENP-A deposition.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-012-1048-8</identifier><identifier>PMID: 22729156</identifier><language>eng</language><publisher>Basel: Springer-Verlag</publisher><subject>Autoantigens - chemistry ; Autoantigens - metabolism ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; cell cycle ; Cellular biology ; Centromere - metabolism ; Centromere Protein A ; chromatids ; Chromatin ; Chromatin - metabolism ; Chromosomal Proteins, Non-Histone - chemistry ; Chromosomal Proteins, Non-Histone - metabolism ; Chromosomes ; Epigenetics ; Epigenomics ; factors ; histones ; Histones - genetics ; Histones - metabolism ; Humans ; kinetochores ; Kinetochores - metabolism ; Life Sciences ; mitosis ; nucleosomes ; Nucleosomes - metabolism ; Protein Structure, Tertiary ; Review ; RNA, Untranslated - metabolism ; S Phase ; segregation</subject><ispartof>Cellular and molecular life sciences : CMLS, 2013-02, Vol.70 (3), p.387-406</ispartof><rights>Springer Basel AG 2012</rights><rights>Springer Basel 2013</rights><rights>Springer Basel AG 2012 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-34fcfc71d9900a64528e8c011856f79f418af2ec81590282bd4951ed7c70dccd3</citedby><cites>FETCH-LOGICAL-c494t-34fcfc71d9900a64528e8c011856f79f418af2ec81590282bd4951ed7c70dccd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084702/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084702/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,41493,42562,51324,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22729156$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stellfox, Madison E</creatorcontrib><creatorcontrib>Bailey, Aaron O</creatorcontrib><creatorcontrib>Foltz, Daniel R</creatorcontrib><title>Putting CENP-A in its place</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>The centromere is the chromosomal region that directs kinetochore assembly during mitosis in order to facilitate the faithful segregation of sister chromatids. The location of the human centromere is epigenetically specified. The presence of nucleosomes that contain the histone H3 variant, CENP-A, are thought to be the epigenetic mark that indicates active centromeres. Maintenance of centromeric identity requires the deposition of new CENP-A nucleosomes with each cell cycle. During S-phase, existing CENP-A nucleosomes are divided among the daughter chromosomes, while new CENP-A nucleosomes are deposited during early G1. The specific assembly of CENP-A nucleosomes at centromeres requires the Mis18 complex, which recruits the CENP-A assembly factor, HJURP. We will review the unique features of centromeric chromatin as well as the mechanism of CENP-A nucleosome deposition. We will also highlight a few recent discoveries that begin to elucidate the factors that temporally and spatially control CENP-A deposition.</description><subject>Autoantigens - chemistry</subject><subject>Autoantigens - metabolism</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>cell cycle</subject><subject>Cellular biology</subject><subject>Centromere - metabolism</subject><subject>Centromere Protein A</subject><subject>chromatids</subject><subject>Chromatin</subject><subject>Chromatin - metabolism</subject><subject>Chromosomal Proteins, Non-Histone - chemistry</subject><subject>Chromosomal Proteins, Non-Histone - metabolism</subject><subject>Chromosomes</subject><subject>Epigenetics</subject><subject>Epigenomics</subject><subject>factors</subject><subject>histones</subject><subject>Histones - genetics</subject><subject>Histones - metabolism</subject><subject>Humans</subject><subject>kinetochores</subject><subject>Kinetochores - metabolism</subject><subject>Life Sciences</subject><subject>mitosis</subject><subject>nucleosomes</subject><subject>Nucleosomes - metabolism</subject><subject>Protein Structure, Tertiary</subject><subject>Review</subject><subject>RNA, Untranslated - metabolism</subject><subject>S Phase</subject><subject>segregation</subject><issn>1420-682X</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kE1LxDAQhoMofv8AEXTBi5fqzDRtkosgi18gKqjgLcQ0XSvddk1awX9vlq6iHjzNwDzvOzMvYzsIRwggjgMAoEwAKUHgMpFLbB05QaJA4PKizyU9rbGNEF4jnEnKV9kakSCFWb7Odu_6rquayWh8dnOXnI6qZlR1YTSrjXVbbKU0dXDbi7rJHs_PHsaXyfXtxdX49DqxXPEuSXlpSyuwUArA5Dwj6aQFRJnlpVAlR2lKclZipoAkPRdcZegKYQUU1hbpJjsZfGf989QV1jWdN7We-Wpq_IduTaV_T5rqRU_ad81BcgEUDQ4XBr59613o9LQK1tW1aVzbB40kUp6qeFBED_6gr23vm_jenIKUc5mnkcKBsr4Nwbvy-xgEPY9eD9HrGL2eR69l1Oz9_OJb8ZV1BGgAQhw1E-d_rP7HdX8QlabVZuKroB_vCTCfkzmRSj8BwPGUtw</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Stellfox, Madison E</creator><creator>Bailey, Aaron O</creator><creator>Foltz, Daniel R</creator><general>Springer-Verlag</general><general>SP Birkhäuser Verlag Basel</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130201</creationdate><title>Putting CENP-A in its place</title><author>Stellfox, Madison E ; Bailey, Aaron O ; Foltz, Daniel R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-34fcfc71d9900a64528e8c011856f79f418af2ec81590282bd4951ed7c70dccd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Autoantigens - chemistry</topic><topic>Autoantigens - metabolism</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>cell cycle</topic><topic>Cellular biology</topic><topic>Centromere - metabolism</topic><topic>Centromere Protein A</topic><topic>chromatids</topic><topic>Chromatin</topic><topic>Chromatin - metabolism</topic><topic>Chromosomal Proteins, Non-Histone - chemistry</topic><topic>Chromosomal Proteins, Non-Histone - metabolism</topic><topic>Chromosomes</topic><topic>Epigenetics</topic><topic>Epigenomics</topic><topic>factors</topic><topic>histones</topic><topic>Histones - genetics</topic><topic>Histones - metabolism</topic><topic>Humans</topic><topic>kinetochores</topic><topic>Kinetochores - metabolism</topic><topic>Life Sciences</topic><topic>mitosis</topic><topic>nucleosomes</topic><topic>Nucleosomes - metabolism</topic><topic>Protein Structure, Tertiary</topic><topic>Review</topic><topic>RNA, Untranslated - metabolism</topic><topic>S Phase</topic><topic>segregation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stellfox, Madison E</creatorcontrib><creatorcontrib>Bailey, Aaron O</creatorcontrib><creatorcontrib>Foltz, Daniel R</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Agriculture & Environmental Science Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular and molecular life sciences : CMLS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stellfox, Madison E</au><au>Bailey, Aaron O</au><au>Foltz, Daniel R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Putting CENP-A in its place</atitle><jtitle>Cellular and molecular life sciences : CMLS</jtitle><stitle>Cell. Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>70</volume><issue>3</issue><spage>387</spage><epage>406</epage><pages>387-406</pages><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>The centromere is the chromosomal region that directs kinetochore assembly during mitosis in order to facilitate the faithful segregation of sister chromatids. The location of the human centromere is epigenetically specified. The presence of nucleosomes that contain the histone H3 variant, CENP-A, are thought to be the epigenetic mark that indicates active centromeres. Maintenance of centromeric identity requires the deposition of new CENP-A nucleosomes with each cell cycle. During S-phase, existing CENP-A nucleosomes are divided among the daughter chromosomes, while new CENP-A nucleosomes are deposited during early G1. The specific assembly of CENP-A nucleosomes at centromeres requires the Mis18 complex, which recruits the CENP-A assembly factor, HJURP. We will review the unique features of centromeric chromatin as well as the mechanism of CENP-A nucleosome deposition. We will also highlight a few recent discoveries that begin to elucidate the factors that temporally and spatially control CENP-A deposition.</abstract><cop>Basel</cop><pub>Springer-Verlag</pub><pmid>22729156</pmid><doi>10.1007/s00018-012-1048-8</doi><tpages>20</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Autoantigens - chemistry Autoantigens - metabolism Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology cell cycle Cellular biology Centromere - metabolism Centromere Protein A chromatids Chromatin Chromatin - metabolism Chromosomal Proteins, Non-Histone - chemistry Chromosomal Proteins, Non-Histone - metabolism Chromosomes Epigenetics Epigenomics factors histones Histones - genetics Histones - metabolism Humans kinetochores Kinetochores - metabolism Life Sciences mitosis nucleosomes Nucleosomes - metabolism Protein Structure, Tertiary Review RNA, Untranslated - metabolism S Phase segregation |
| title | Putting CENP-A in its place |
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