Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase

Chromosome translocations involving antigen receptor loci are a genetic hallmark of non-Hodgkin's lymphomas in humans. Most commonly, these translocations result in juxtaposition of the immunoglobulin heavy-chain (IgH) locus with one of several cellular proto-oncogenes, leading to deregulated o...

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Veröffentlicht in:	The Journal of clinical investigation 1999-06, Vol.103 (12), p.1669-1675
Hauptverfasser:	Vanasse, G J, Halbrook, J, Thomas, S, Burgess, A, Hoekstra, M F, Disteche, C M, Willerford, D M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - immunology DNA Nucleotidyltransferases - genetics Gene Rearrangement, B-Lymphocyte, Heavy Chain Immunoglobulin Heavy Chains - genetics Immunophenotyping Lymphoma, B-Cell - enzymology Lymphoma, B-Cell - genetics Lymphoma, B-Cell - immunology Mice Mice, Inbred C57BL Mice, Inbred ICR Mice, Knockout Mice, SCID Receptors, Antigen, B-Cell - genetics Stem Cells - immunology Translocation, Genetic - immunology Tumor Suppressor Protein p53 - deficiency Tumor Suppressor Protein p53 - genetics VDJ Recombinases
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