Chronic Neuroinflammation in Alzheimer’s Disease : New Perspectives on Animal Models and Promising Candidate Drugs

Chronic neuroinflammation is now considered one of the major factors in the pathogenesis of Alzheimer’s disease (AD). However, the most widely used transgenic AD models (overexpressing mutated forms of amyloid precursor protein, presenilin, and/or tau) do not demonstrate the degree of inflammation,...

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Veröffentlicht in:	BioMed research international 2014-01, Vol.2014 (2014), p.1-10
Hauptverfasser:	Münch, Gerald, Campbell, Iain L., Aldrich-Wright, Janice R., Gyengesi, Erika, Rangel, Alejandra, Karunaweera, Niloo, Millington, Christopher, Sonego, Sandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - metabolism Animal cognition Animals Astrocytes - metabolism Astrocytes - pathology Brain Clinical trials Cytokines Development and progression Disease Models, Animal Drug therapy Glial Fibrillary Acidic Protein Humans Hypotheses Inflammation Inflammation - drug therapy Inflammation - genetics Inflammation - pathology Interleukin-6 - genetics Medical research Medicine, Experimental Mice Mice, Transgenic Nerve Tissue Proteins - genetics Neurodegeneration Proteins Review Rodents Studies
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