Regulation of Mitochondrial Genome Inheritance by Autophagy and Ubiquitin-Proteasome System : Implications for Health, Fitness, and Fertility

Mitochondria, the energy-generating organelles, play a role in numerous cellular functions including adenosine triphosphate (ATP) production, cellular homeostasis, and apoptosis. Maternal inheritance of mitochondria and mitochondrial DNA (mtDNA) is universally observed in humans and most animals. In...

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Veröffentlicht in:	BioMed research international 2014-01, Vol.2014 (2014), p.1-16
Hauptverfasser:	Song, Won-Hee, Ballard, John William Oman, Yi, Young-Joo, Sutovsky, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Apoptosis Autophagy Autophagy (Cytology) Autophagy - physiology Biomedical research Cell cycle Colleges & universities Deoxyribonucleic acid DNA Embryos Female Fertility Fertility - physiology Genes Genetic regulation Genome, Mitochondrial - physiology Genomes Humans Infertility Influence Male Mammals Mitochondria Mitochondrial Degradation - physiology Mitochondrial DNA Oocytes - metabolism Phosphorylation Proteasome Endopeptidase Complex - physiology Proteins Proteolysis Review Sperm Sperm Maturation - physiology Spermatogenesis Spermatozoa - metabolism Ubiquitin - metabolism Womens health
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