The AVPR1A Gene and Substance Use Disorders: Association, Replication, and Functional Evidence

Background The liability to addiction has been shown to be highly genetically correlated across drug classes, suggesting nondrug-specific mechanisms. Methods In 757 subjects, we performed association analysis between 1536 single nucleotide polymorphisms (SNPs) in 106 candidate genes and a drug use d...

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Veröffentlicht in:	Biological psychiatry (1969) 2011-09, Vol.70 (6), p.519-527
Hauptverfasser:	Maher, Brion S, Vladimirov, Vladimir I, Latendresse, Shawn J, Thiselton, Dawn L, McNamee, Rebecca, Kang, Moonsu, Bigdeli, Tim B, Chen, Xiangning, Riley, Brien P, Hettema, John M, Chilcoat, Howard, Heidbreder, Christian, Muglia, Pierandrea, Murrelle, E. Lenn, Dick, Danielle M, Aliev, Fazil, Agrawal, Arpana, Edenberg, Howard J, Kramer, John, Nurnberger, John, Tischfield, Jay A, Devlin, Bernie, Ferrell, Robert E, Kirillova, Galina P, Tarter, Ralph E, Kendler, Kenneth S, Vanyukov, Michael M
Format:	Artikel
Sprache:	eng
Schlagworte:	Addiction Adolescent Adult alcoholism Arginine Vasopressin - genetics Brain - metabolism Case-Control Studies Child Female gene systems genetic association Genetic Association Studies - statistics & numerical data Humans Male Object Attachment Polymorphism, Single Nucleotide - genetics Psychiatry Receptors, Vasopressin - biosynthesis Receptors, Vasopressin - genetics Sex Characteristics social relationships Spouses - psychology Substance-Related Disorders - genetics Substance-Related Disorders - psychology Twins - genetics Twins - psychology vasopressin
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