Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4

The small ubiquitin-like modifier (SUMO) can form polymeric chains that are important signals in cellular processes such as meiosis, genome maintenance and stress response. The SUMO-targeted ubiquitin ligase RNF4 engages with SUMO chains on linked substrates and catalyses their ubiquitination, which...

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Veröffentlicht in:	Nature communications 2014-06, Vol.5 (1), p.4217, Article 4217
Hauptverfasser:	Xu, Yingqi, Plechanovová, Anna, Simpson, Peter, Marchant, Jan, Leidecker, Orsolya, Kraatz, Sebastian, Hay, Ronald T., Matthews, Steve J.
Format:	Artikel
Sprache:	eng
Schlagworte:	101/1 101/6 140/131 631/45/474/2073 631/45/474/538 631/45/535 82/16 82/80 Amino Acid Motifs DNA repair Enzymes Humanities and Social Sciences Humans Leukemia Life sciences multidisciplinary NMR Nuclear magnetic resonance Nuclear Proteins - metabolism Proteasome Endopeptidase Complex Protein Interaction Mapping Proteins Science Science (multidisciplinary) Signal transduction Small Ubiquitin-Related Modifier Proteins - metabolism Spectrum analysis Transcription Factors - metabolism Ubiquitination - physiology
Online-Zugang:	Volltext
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