$Allogeneic natural killer cells for refractory lymphoma$

Allogeneic natural killer cells for refractory lymphoma

We reported that IL-2 activated autologous NK cells can induce, but not maintain durable remissions in lymphoma patients. We hypothesized that allogeneic NK cells may overcome class I MHC-mediated inhibition of NK cell killing. In a pilot study, we evaluated infusion of haploidentical donor NK cells...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2010-11, Vol.59 (11), p.1739-1744
Hauptverfasser:	Bachanova, Veronika, Burns, Linda J, McKenna, David H, Curtsinger, Julie, Panoskaltsis-Mortari, Angela, Lindgren, Bruce R, Cooley, Sarah, Weisdorf, Daniel, Miller, Jeffrey S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive cell therapy Adult Aged Allogeneic NK cells Antineoplastic agents Biological and medical sciences Blood Cancer Cancer Research Cells Chemotherapy Cytotoxicity Enzyme-Linked Immunosorbent Assay Hematologic and hematopoietic diseases Humans Immunology Immunotherapy Interleukin-2 - therapeutic use Killer Cells, Natural - cytology Killer Cells, Natural - transplantation Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocyte Activation Lymphocytes Lymphoma Lymphoma, Non-Hodgkin - immunology Lymphoma, Non-Hodgkin - therapy Medical sciences Medicine Medicine & Public Health Middle Aged Oncology Pharmacology. Drug treatments Pilot Projects Prospective Studies Remission (Medicine) Salvage Therapy Short Communication Statistical analysis Survival Rate T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - immunology Transplantation, Homologous Transplants & implants Treatment Outcome
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