Influence of aeration–homogenization system in stirred tank bioreactors, dissolved oxygen concentration and pH control mode on BHK-21 cell growth and metabolism

This work focused on determining the effect of dissolved oxygen concentration (DO) on growth and metabolism of BHK-21 cell line (host cell for recombinant proteins manufacturing and viral vaccines) cultured in two stirred tank bioreactors with different aeration-homogenization systems, as well as pH...

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Veröffentlicht in:	Cytotechnology (Dordrecht) 2014-08, Vol.66 (4), p.605-617
Hauptverfasser:	Núñez, Eutimio Gustavo Fernández, Leme, Jaci, de Almeida Parizotto, Letícia, Chagas, Wagner Antonio, de Rezende, Alexandre Gonçalves, da Costa, Bruno Labate Vale, Monteiro, Daniela Cristina Ventini, Boldorini, Vera Lucia Lopes, Jorge, Soraia Attie Calil, Astray, Renato Mancini, Pereira, Carlos Augusto, Caricati, Celso Pereira, Tonso, Aldo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aeration Ammonia Aqueous solutions Biochemistry Biomedicine Bioreactors Biotechnology Carbon dioxide Cell culture Cell growth Cell size Chemistry Chemistry and Materials Science Dissolved oxygen Gas flow Gene therapy Glucose Homogenization Metabolism Metabolites Original Research Oxygen consumption pH effects Sodium bicarbonate Vaccines
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