Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle

Hematopoietic stem cells (HSCs) maintain homeostasis and regenerate the blood system throughout life. It has been postulated that HSCs may be uniquely capable of preserving their genomic integrity in order to ensure lifelong function. To directly test this, we quantified DNA damage in HSCs and downs...

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Veröffentlicht in:	Cell stem cell 2014-07, Vol.15 (1), p.37-50
Hauptverfasser:	Beerman, Isabel, Seita, Jun, Inlay, Matthew A., Weissman, Irving L., Rossi, Derrick J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Bone Marrow Cells - physiology Carcinogenesis - genetics Cell Cycle Checkpoints - genetics Cells, Cultured DNA Damage DNA Repair Hematopoietic Stem Cells - physiology Homeostasis Mice Mice, Inbred C57BL Microarray Analysis Mutation - genetics Transplantation Chimera
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