Effect of gastric acid suppressants and prokinetics on peritoneal dialysis-related peritonitis
AIM: To investigate the effect of gastric acid suppressants and prokinetics on peritonitis development in peritoneal dialysis(PD) patients.METHODS: This was a single-center, retrospective study. The medical records of 398 PD patients were collected from January 2000 to September 2012 and analyzed to...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2014-07, Vol.20 (25), p.8187-8194 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Kwon, Ji Eun Koh, Seong-Joon Chun, Jaeyoung Kim, Ji Won Kim, Byeong Gwan Lee, Kook Lae Im, Jong Pil Kim, Joo Sung Jung, Hyun Chae |
| description | AIM: To investigate the effect of gastric acid suppressants and prokinetics on peritonitis development in peritoneal dialysis(PD) patients.METHODS: This was a single-center, retrospective study. The medical records of 398 PD patients were collected from January 2000 to September 2012 and analyzed to compare patients with at least one episode of peritonitis(peritonitis group, group A) to patients who never had peritonitis(no peritonitis group, group B). All peritonitis episodes were analyzed to compare peritonitis caused by enteric organisms and peritonitis caused by non-enteric organisms.RESULTS: Among the 120 patients who met the inclusion criteria, 61 patients had at least one episode ofperitonitis and 59 patients never experienced peritonitis. Twenty-four of 61 patients(39.3%) in group A and 15 of 59 patients(25.4%) in group B used gastric acid suppressants. Only the use of H2-blocker(H2B) was associated with an increased risk of PD-related peritonitis; the use of proton pump inhibitors, other antacids, and prokinetics was not found to be a significant risk factor for PD-related peritonitis. A total of 81 episodes of peritonitis were divided into enteric peritonitis(EP) or non-enteric peritonitis, depending on the causative organism, and gastric acid suppressants and prokinetics did not increase the risk of EP in PD patients.CONCLUSION: The use of H2B showed a trend for an increased risk of overall PD-related peritonitis, although further studies are required to clarify the effects of drugs on PD-related peritonitis. |
| doi_str_mv | 10.3748/wjg.v20.i25.8187 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4081691</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>90888889504849525053485052</cqvip_id><sourcerecordid>25057226</sourcerecordid><originalsourceid>FETCH-LOGICAL-c440t-f1d15acf7a9c46d2ba8f108fb2359e2e28738f6c4e0aada8e10cf1e8237bfa8e3</originalsourceid><addsrcrecordid>eNpVkEFP3DAQha2qqCzQe0-V_0CW8djZOJdK1YrSSiv1Uq5Ys44dTLNOanup-PdkBaxgDjMavXlvpI-xLwKWslH68v99v3xAWAasl1ro5gNbIIq2Qq3gI1sIgKZqJTan7CznewCUssZP7BRrqBvE1YLdXnnvbOGj5z3lkoLlZEPH836aksuZYsmcYsenNP4N0ZVgMx8jn1wKZYyOBt4FGh5zyFVyAxXXvWqhhHzBTjwN2X1-mefs5sfVn_XPavP7-tf6-6aySkGpvOhETdY31Fq16nBL2gvQfouybh061I3UfmWVA6KOtBNgvXAaZbP18yrP2bfn3Gm_3bnOulgSDWZKYUfp0YwUzHslhjvTjw9GgRarVswB8Bxg05hzcv7oFWAOrM3M2syszczaHFjPlq9vfx4Nr3DnA_mSeTfG_l-I_fGmBX2otgalVVsfLFLpuaN8AqoJj4s</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Effect of gastric acid suppressants and prokinetics on peritoneal dialysis-related peritonitis</title><source>MEDLINE</source><source>Baishideng "World Journal of" online journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Kwon, Ji Eun ; Koh, Seong-Joon ; Chun, Jaeyoung ; Kim, Ji Won ; Kim, Byeong Gwan ; Lee, Kook Lae ; Im, Jong Pil ; Kim, Joo Sung ; Jung, Hyun Chae</creator><creatorcontrib>Kwon, Ji Eun ; Koh, Seong-Joon ; Chun, Jaeyoung ; Kim, Ji Won ; Kim, Byeong Gwan ; Lee, Kook Lae ; Im, Jong Pil ; Kim, Joo Sung ; Jung, Hyun Chae</creatorcontrib><description>AIM: To investigate the effect of gastric acid suppressants and prokinetics on peritonitis development in peritoneal dialysis(PD) patients.METHODS: This was a single-center, retrospective study. The medical records of 398 PD patients were collected from January 2000 to September 2012 and analyzed to compare patients with at least one episode of peritonitis(peritonitis group, group A) to patients who never had peritonitis(no peritonitis group, group B). All peritonitis episodes were analyzed to compare peritonitis caused by enteric organisms and peritonitis caused by non-enteric organisms.RESULTS: Among the 120 patients who met the inclusion criteria, 61 patients had at least one episode ofperitonitis and 59 patients never experienced peritonitis. Twenty-four of 61 patients(39.3%) in group A and 15 of 59 patients(25.4%) in group B used gastric acid suppressants. Only the use of H2-blocker(H2B) was associated with an increased risk of PD-related peritonitis; the use of proton pump inhibitors, other antacids, and prokinetics was not found to be a significant risk factor for PD-related peritonitis. A total of 81 episodes of peritonitis were divided into enteric peritonitis(EP) or non-enteric peritonitis, depending on the causative organism, and gastric acid suppressants and prokinetics did not increase the risk of EP in PD patients.CONCLUSION: The use of H2B showed a trend for an increased risk of overall PD-related peritonitis, although further studies are required to clarify the effects of drugs on PD-related peritonitis.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v20.i25.8187</identifier><identifier>PMID: 25057226</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Inc</publisher><subject>Adult ; Aged ; Antacids - adverse effects ; antago ; Female ; Gastrointestinal Agents - adverse effects ; Gastrointestinal Motility - drug effects ; Gastrointestinal Tract - drug effects ; Gastrointestinal Tract - microbiology ; Gastrointestinal Tract - physiopathology ; Histamine ; Histamine H2 Antagonists - adverse effects ; Humans ; inhibitors ; Male ; Middle Aged ; Peritoneal Dialysis - adverse effects ; Peritonitis - etiology ; Peritonitis - microbiology ; Peritonitis - physiopathology ; Proton ; Proton Pump Inhibitors - adverse effects ; pump ; receptor ; Republic of Korea ; Retrospective Studies ; Retrospective Study ; Risk Assessment ; Risk Factors ; Young Adult</subject><ispartof>World journal of gastroenterology : WJG, 2014-07, Vol.20 (25), p.8187-8194</ispartof><rights>2014 Baishideng Publishing Group Inc. All rights reserved. 2014</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-f1d15acf7a9c46d2ba8f108fb2359e2e28738f6c4e0aada8e10cf1e8237bfa8e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081691/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081691/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25057226$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwon, Ji Eun</creatorcontrib><creatorcontrib>Koh, Seong-Joon</creatorcontrib><creatorcontrib>Chun, Jaeyoung</creatorcontrib><creatorcontrib>Kim, Ji Won</creatorcontrib><creatorcontrib>Kim, Byeong Gwan</creatorcontrib><creatorcontrib>Lee, Kook Lae</creatorcontrib><creatorcontrib>Im, Jong Pil</creatorcontrib><creatorcontrib>Kim, Joo Sung</creatorcontrib><creatorcontrib>Jung, Hyun Chae</creatorcontrib><title>Effect of gastric acid suppressants and prokinetics on peritoneal dialysis-related peritonitis</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM: To investigate the effect of gastric acid suppressants and prokinetics on peritonitis development in peritoneal dialysis(PD) patients.METHODS: This was a single-center, retrospective study. The medical records of 398 PD patients were collected from January 2000 to September 2012 and analyzed to compare patients with at least one episode of peritonitis(peritonitis group, group A) to patients who never had peritonitis(no peritonitis group, group B). All peritonitis episodes were analyzed to compare peritonitis caused by enteric organisms and peritonitis caused by non-enteric organisms.RESULTS: Among the 120 patients who met the inclusion criteria, 61 patients had at least one episode ofperitonitis and 59 patients never experienced peritonitis. Twenty-four of 61 patients(39.3%) in group A and 15 of 59 patients(25.4%) in group B used gastric acid suppressants. Only the use of H2-blocker(H2B) was associated with an increased risk of PD-related peritonitis; the use of proton pump inhibitors, other antacids, and prokinetics was not found to be a significant risk factor for PD-related peritonitis. A total of 81 episodes of peritonitis were divided into enteric peritonitis(EP) or non-enteric peritonitis, depending on the causative organism, and gastric acid suppressants and prokinetics did not increase the risk of EP in PD patients.CONCLUSION: The use of H2B showed a trend for an increased risk of overall PD-related peritonitis, although further studies are required to clarify the effects of drugs on PD-related peritonitis.</description><subject>Adult</subject><subject>Aged</subject><subject>Antacids - adverse effects</subject><subject>antago</subject><subject>Female</subject><subject>Gastrointestinal Agents - adverse effects</subject><subject>Gastrointestinal Motility - drug effects</subject><subject>Gastrointestinal Tract - drug effects</subject><subject>Gastrointestinal Tract - microbiology</subject><subject>Gastrointestinal Tract - physiopathology</subject><subject>Histamine</subject><subject>Histamine H2 Antagonists - adverse effects</subject><subject>Humans</subject><subject>inhibitors</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Peritoneal Dialysis - adverse effects</subject><subject>Peritonitis - etiology</subject><subject>Peritonitis - microbiology</subject><subject>Peritonitis - physiopathology</subject><subject>Proton</subject><subject>Proton Pump Inhibitors - adverse effects</subject><subject>pump</subject><subject>receptor</subject><subject>Republic of Korea</subject><subject>Retrospective Studies</subject><subject>Retrospective Study</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Young Adult</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEFP3DAQha2qqCzQe0-V_0CW8djZOJdK1YrSSiv1Uq5Ys44dTLNOanup-PdkBaxgDjMavXlvpI-xLwKWslH68v99v3xAWAasl1ro5gNbIIq2Qq3gI1sIgKZqJTan7CznewCUssZP7BRrqBvE1YLdXnnvbOGj5z3lkoLlZEPH836aksuZYsmcYsenNP4N0ZVgMx8jn1wKZYyOBt4FGh5zyFVyAxXXvWqhhHzBTjwN2X1-mefs5sfVn_XPavP7-tf6-6aySkGpvOhETdY31Fq16nBL2gvQfouybh061I3UfmWVA6KOtBNgvXAaZbP18yrP2bfn3Gm_3bnOulgSDWZKYUfp0YwUzHslhjvTjw9GgRarVswB8Bxg05hzcv7oFWAOrM3M2syszczaHFjPlq9vfx4Nr3DnA_mSeTfG_l-I_fGmBX2otgalVVsfLFLpuaN8AqoJj4s</recordid><startdate>20140707</startdate><enddate>20140707</enddate><creator>Kwon, Ji Eun</creator><creator>Koh, Seong-Joon</creator><creator>Chun, Jaeyoung</creator><creator>Kim, Ji Won</creator><creator>Kim, Byeong Gwan</creator><creator>Lee, Kook Lae</creator><creator>Im, Jong Pil</creator><creator>Kim, Joo Sung</creator><creator>Jung, Hyun Chae</creator><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20140707</creationdate><title>Effect of gastric acid suppressants and prokinetics on peritoneal dialysis-related peritonitis</title><author>Kwon, Ji Eun ; 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The medical records of 398 PD patients were collected from January 2000 to September 2012 and analyzed to compare patients with at least one episode of peritonitis(peritonitis group, group A) to patients who never had peritonitis(no peritonitis group, group B). All peritonitis episodes were analyzed to compare peritonitis caused by enteric organisms and peritonitis caused by non-enteric organisms.RESULTS: Among the 120 patients who met the inclusion criteria, 61 patients had at least one episode ofperitonitis and 59 patients never experienced peritonitis. Twenty-four of 61 patients(39.3%) in group A and 15 of 59 patients(25.4%) in group B used gastric acid suppressants. Only the use of H2-blocker(H2B) was associated with an increased risk of PD-related peritonitis; the use of proton pump inhibitors, other antacids, and prokinetics was not found to be a significant risk factor for PD-related peritonitis. A total of 81 episodes of peritonitis were divided into enteric peritonitis(EP) or non-enteric peritonitis, depending on the causative organism, and gastric acid suppressants and prokinetics did not increase the risk of EP in PD patients.CONCLUSION: The use of H2B showed a trend for an increased risk of overall PD-related peritonitis, although further studies are required to clarify the effects of drugs on PD-related peritonitis.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>25057226</pmid><doi>10.3748/wjg.v20.i25.8187</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Antacids - adverse effects antago Female Gastrointestinal Agents - adverse effects Gastrointestinal Motility - drug effects Gastrointestinal Tract - drug effects Gastrointestinal Tract - microbiology Gastrointestinal Tract - physiopathology Histamine Histamine H2 Antagonists - adverse effects Humans inhibitors Male Middle Aged Peritoneal Dialysis - adverse effects Peritonitis - etiology Peritonitis - microbiology Peritonitis - physiopathology Proton Proton Pump Inhibitors - adverse effects pump receptor Republic of Korea Retrospective Studies Retrospective Study Risk Assessment Risk Factors Young Adult |
| title | Effect of gastric acid suppressants and prokinetics on peritoneal dialysis-related peritonitis |
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