A basic science view of acute kidney injury biomarkers
Over the last decade, significant progress has been made in the identification and validation of novel biomarkers as well as refinements in the use of serum creatinine as a marker of kidney function. These advances have taken advantage of laboratory investigations, which have identified these novel...
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| Veröffentlicht in: | Nephrology, dialysis, transplantation dialysis, transplantation, 2014-07, Vol.29 (7), p.1301-1311 |
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| container_title | Nephrology, dialysis, transplantation |
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| creator | Charlton, Jennifer R Portilla, Didier Okusa, Mark D |
| description | Over the last decade, significant progress has been made in the identification and validation of novel biomarkers as well as refinements in the use of serum creatinine as a marker of kidney function. These advances have taken advantage of laboratory investigations, which have identified these novel molecules that serve important biological functions in the pathogenesis of acute kidney injury (AKI). As we advance and validate these markers for clinical studies in AKI, we recognize that they serve not only to improve our understanding of AKI, but they could also serve as potential targets for the treatment of AKI. This review will underscore the biological basis of specific biomarkers that will contribute to the advancement in the treatment and outcomes of AKI. |
| doi_str_mv | 10.1093/ndt/gft510 |
| format | Article |
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This review will underscore the biological basis of specific biomarkers that will contribute to the advancement in the treatment and outcomes of AKI.</description><subject>Acute Kidney Injury - blood</subject><subject>Acute Kidney Injury - diagnosis</subject><subject>Acute Kidney Injury - urine</subject><subject>Animals</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - urine</subject><subject>Cutting-Edge Renal Science</subject><subject>Humans</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEtLAzEUhYMotlY3_gDJUoSxSSaZyWyEUnxBwY2uQx53atrpTE1mKv33TmkturqL83Hu4UPompJ7Sop0XLt2PC9bQckJGlKekYSlUpyiYR_ShAhSDNBFjAtCSMHy_BwNGO8BwcUQZRNsdPQWR-uhtoA3Hr5xU2Jtuxbw0rsattjXiy5ssfHNSoclhHiJzkpdRbg63BH6eHp8n74ks7fn1-lklljOeZtwLR2zoC1nGQMtCimd05RwTTTVvIRU8ozlJgNjXcGZLozJBaOFcRmnXKYj9LDvXXdmBc5C3QZdqXXw_ZCtarRX_5Paf6p5s1GcSJqlrC-4PRSE5quD2KqVjxaqStfQdFFRwWkqaZ7v0Ls9akMTY4Dy-IYStROtetFqL7qHb_4OO6K_ZtMf5tV6zw</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Charlton, Jennifer R</creator><creator>Portilla, Didier</creator><creator>Okusa, Mark D</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140701</creationdate><title>A basic science view of acute kidney injury biomarkers</title><author>Charlton, Jennifer R ; Portilla, Didier ; Okusa, Mark D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-4a8d2ceac4262ea5988dda104a0a1a4fe384627b6ebcd942a9bb75219bd641483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acute Kidney Injury - blood</topic><topic>Acute Kidney Injury - diagnosis</topic><topic>Acute Kidney Injury - urine</topic><topic>Animals</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - urine</topic><topic>Cutting-Edge Renal Science</topic><topic>Humans</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Charlton, Jennifer R</creatorcontrib><creatorcontrib>Portilla, Didier</creatorcontrib><creatorcontrib>Okusa, Mark D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Charlton, Jennifer R</au><au>Portilla, Didier</au><au>Okusa, Mark D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A basic science view of acute kidney injury biomarkers</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol Dial Transplant</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>29</volume><issue>7</issue><spage>1301</spage><epage>1311</epage><pages>1301-1311</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><abstract>Over the last decade, significant progress has been made in the identification and validation of novel biomarkers as well as refinements in the use of serum creatinine as a marker of kidney function. 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| fulltext | fulltext |
| identifier | ISSN: 0931-0509 |
| ispartof | Nephrology, dialysis, transplantation, 2014-07, Vol.29 (7), p.1301-1311 |
| issn | 0931-0509 1460-2385 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4081632 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Acute Kidney Injury - blood Acute Kidney Injury - diagnosis Acute Kidney Injury - urine Animals Biomarkers - blood Biomarkers - urine Cutting-Edge Renal Science Humans |
| title | A basic science view of acute kidney injury biomarkers |
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