The Rho-kinase inhibitor HA-1077 suppresses proliferation/migration and induces apoptosis of urothelial cancer cells

Activation of Rho, one of the small GTPases, and its major downstream target Rho-kinase (ROCK) promotes the development and metastasis of cancer. We previously showed that elevation of Rho and ROCK expression was associated with tumor invasion, metastasis, and an unfavorable prognosis in patients wi...

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Veröffentlicht in:	BMC cancer 2014-06, Vol.14 (1), p.412-412, Article 412
Hauptverfasser:	Abe, Hideyuki, Kamai, Takao, Hayashi, Keitaro, Anzai, Naohiko, Shirataki, Hiromichi, Mizuno, Tomoya, Yamaguchi, Yoshiyuki, Masuda, Akinori, Yuki, Hideo, Betsunoh, Hironori, Yashi, Masahiro, Fukabori, Yoshitatsu, Yoshida, Ken-Ichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology Apoptosis Apoptosis - drug effects Bladder cancer Cancer therapies Cell culture Cell growth Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cytoskeleton Humans Hypertension Immunohistochemistry Kinases Medical prognosis Metastasis Protein Kinase Inhibitors - pharmacology Proteins rho-Associated Kinases - antagonists & inhibitors Studies Tumor Stem Cell Assay Urinary Bladder Neoplasms - metabolism Urogenital system Urologic Neoplasms - metabolism
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