Surfactant protein A suppresses reactive nitrogen intermediates by alveolar macrophages in response to Mycobacterium tuberculosis

Mycobacterium tuberculosis attaches to, enters, and replicates within alveolar macrophages (AMs). Our previous studies suggest that surfactant protein A (SP-A) can act as a ligand in the attachment of M. tuberculosis to AMs. Reactive nitrogen intermediates (RNIs) play a significant role in the killi...

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Veröffentlicht in:	The Journal of clinical investigation 1999-02, Vol.103 (4), p.483-490
Hauptverfasser:	Pasula, R, Wright, J R, Kachel, D L, Martin, 2nd, W J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dose-Response Relationship, Drug Humans Interferon-gamma - pharmacology Macrophages, Alveolar - drug effects Macrophages, Alveolar - immunology Macrophages, Alveolar - metabolism Macrophages, Alveolar - microbiology Mice Mitogens - pharmacology Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - immunology Nitrogen - immunology Nitrogen - metabolism Proteolipids - immunology Proteolipids - pharmacology Pulmonary Surfactant-Associated Protein A Pulmonary Surfactant-Associated Proteins Pulmonary Surfactants - immunology Pulmonary Surfactants - pharmacology Rats
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