Mitochondria‐targeted antioxidant (MitoQ) ameliorates age‐related arterial endothelial dysfunction in mice

Key points The development of age‐related arterial endothelial dysfunction, a key antecedent of increased cardiovascular disease (CVD) risk, is mediated largely by reduced nitric oxide bioavailability as a consequence of oxidative stress. Mitochondria are critical signalling organelles in the vascul...

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Veröffentlicht in:	The Journal of physiology 2014-06, Vol.592 (12), p.2549-2561
Hauptverfasser:	Gioscia‐Ryan, Rachel A., LaRocca, Thomas J., Sindler, Amy L., Zigler, Melanie C., Murphy, Michael P., Seals, Douglas R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Antioxidants - pharmacology Antioxidants - therapeutic use Aorta, Thoracic - drug effects Aorta, Thoracic - physiology Cardiovascular Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Male Mice, Inbred C57BL Mitochondria - drug effects Mitochondria - metabolism Nitric Oxide - metabolism Nitric Oxide Synthase - metabolism Organophosphorus Compounds - pharmacology Organophosphorus Compounds - therapeutic use Oxidative Stress - drug effects Superoxides - metabolism Ubiquinone - analogs & derivatives Ubiquinone - pharmacology Ubiquinone - therapeutic use Vascular Diseases - drug therapy Vascular Diseases - metabolism Vascular Diseases - physiopathology Vasodilation - drug effects
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