Gefitinib-induced skin ulceration in metastatic adenocarcinoma lung
Abstract We report a case of gefitinib-induced skin ulceration in a 50-year-old female with metastatic adenocarcinoma of lung who developed this adverse effect 2 weeks following initiation of gefitinib at a dose of 250 mg/day. The ulcer improved with stopping gefitinib for 2 weeks and also addition...
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| Veröffentlicht in: | Indian journal of medical and paediatric oncology 2014-01, Vol.35 (1), p.109-110 |
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| container_title | Indian journal of medical and paediatric oncology |
| container_volume | 35 |
| creator | Sathyanarayanan, Vishwanath Lokesh, Kadabur Nagendrappa Channaviriappa, Lakshmaiah Kuntejowdahalli Jacob, Linu Abraham |
| description | Abstract
We report a case of gefitinib-induced skin ulceration in a 50-year-old female with metastatic adenocarcinoma of lung who developed this adverse effect 2 weeks following initiation of gefitinib at a dose of 250 mg/day. The ulcer improved with stopping gefitinib for 2 weeks and also addition of topical steroids and antibiotics. We are reporting this case to create awareness among treating oncologists of this adverse effect and also prompt interruption of therapy and topical steroids/antibiotics is useful to treat this adverse event. |
| doi_str_mv | 10.4103/0971-5851.133736 |
| format | Article |
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We report a case of gefitinib-induced skin ulceration in a 50-year-old female with metastatic adenocarcinoma of lung who developed this adverse effect 2 weeks following initiation of gefitinib at a dose of 250 mg/day. The ulcer improved with stopping gefitinib for 2 weeks and also addition of topical steroids and antibiotics. We are reporting this case to create awareness among treating oncologists of this adverse effect and also prompt interruption of therapy and topical steroids/antibiotics is useful to treat this adverse event.</description><identifier>ISSN: 0971-5851</identifier><identifier>EISSN: 0975-2129</identifier><identifier>DOI: 10.4103/0971-5851.133736</identifier><identifier>PMID: 25006299</identifier><language>eng</language><publisher>A-12, 2nd Floor, Sector 2, Noida-201301 UP, India: Thieme Medical and Scientific Publishers Pvt. Ltd</publisher><subject>Adenocarcinoma ; Antibiotics ; CASE REPORT ; Case studies ; Complications and side effects ; Epidermal growth factor ; Gefitinib ; Lung cancer ; Metastasis ; Mutation ; Skin ; Ulcers</subject><ispartof>Indian journal of medical and paediatric oncology, 2014-01, Vol.35 (1), p.109-110</ispartof><rights>Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)</rights><rights>COPYRIGHT 2014 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt Ltd Jan-Mar 2014</rights><rights>Copyright: © Indian Journal of Medical and Paediatric Oncology 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-46f20c42c0426093b771019ce571b273a07cb4d023d26b848de0ce757f2df82d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080647/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080647/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,20890,27923,27924,53790,53792,54586</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25006299$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sathyanarayanan, Vishwanath</creatorcontrib><creatorcontrib>Lokesh, Kadabur Nagendrappa</creatorcontrib><creatorcontrib>Channaviriappa, Lakshmaiah Kuntejowdahalli</creatorcontrib><creatorcontrib>Jacob, Linu Abraham</creatorcontrib><title>Gefitinib-induced skin ulceration in metastatic adenocarcinoma lung</title><title>Indian journal of medical and paediatric oncology</title><addtitle>Indian J Med Paediatr Oncol</addtitle><description>Abstract
We report a case of gefitinib-induced skin ulceration in a 50-year-old female with metastatic adenocarcinoma of lung who developed this adverse effect 2 weeks following initiation of gefitinib at a dose of 250 mg/day. The ulcer improved with stopping gefitinib for 2 weeks and also addition of topical steroids and antibiotics. We are reporting this case to create awareness among treating oncologists of this adverse effect and also prompt interruption of therapy and topical steroids/antibiotics is useful to treat this adverse event.</description><subject>Adenocarcinoma</subject><subject>Antibiotics</subject><subject>CASE REPORT</subject><subject>Case studies</subject><subject>Complications and side effects</subject><subject>Epidermal growth factor</subject><subject>Gefitinib</subject><subject>Lung cancer</subject><subject>Metastasis</subject><subject>Mutation</subject><subject>Skin</subject><subject>Ulcers</subject><issn>0971-5851</issn><issn>0975-2129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>0U6</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1UU1v1DAUjBAVLS13TigSErdsn7-TC1K1goJUqRd6thzb2XVJ7GI7lfj3OKSUXQnkg_3emxn5zVTVWwQbioBcQidQw1qGNogQQfiL6qy0WIMR7l7-fq_j0-p1SvcAhCHevqpOMQPguOvOqu21HVx23vWN82bW1tTpu_P1PGobVXbB16WabFYpl1LXylgftIra-TCpepz97qI6GdSY7Jun-7y6-_zp2_ZLc3N7_XV7ddNohrvcUD5g0BRroJhDR3ohEKBOWyZQjwVRIHRPDWBiMO9b2hoL2gomBmyGFhtyXn1cdR_mfrJGW5-jGuVDdJOKP2VQTh5PvNvLXXiUFFrgVBSB908CMfyYbcryPszRlz9LxAhFBLOW_0Xt1Gil80MoYnpyScsrIoBwALSgNv9AlWPs5HTwxdbSPyJ8OCDsrRrzPoVxXjxOx0BYgTqGlKIdnjdEIJfY5ZKrXHKVa-yF8u7QmWfCn5wL4HIF5L2zkz3Y-3-SvwDfTrOm</recordid><startdate>201401</startdate><enddate>201401</enddate><creator>Sathyanarayanan, Vishwanath</creator><creator>Lokesh, Kadabur Nagendrappa</creator><creator>Channaviriappa, Lakshmaiah Kuntejowdahalli</creator><creator>Jacob, Linu Abraham</creator><general>Thieme Medical and Scientific Publishers Pvt. 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We report a case of gefitinib-induced skin ulceration in a 50-year-old female with metastatic adenocarcinoma of lung who developed this adverse effect 2 weeks following initiation of gefitinib at a dose of 250 mg/day. The ulcer improved with stopping gefitinib for 2 weeks and also addition of topical steroids and antibiotics. We are reporting this case to create awareness among treating oncologists of this adverse effect and also prompt interruption of therapy and topical steroids/antibiotics is useful to treat this adverse event.</abstract><cop>A-12, 2nd Floor, Sector 2, Noida-201301 UP, India</cop><pub>Thieme Medical and Scientific Publishers Pvt. Ltd</pub><pmid>25006299</pmid><doi>10.4103/0971-5851.133736</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Indian journal of medical and paediatric oncology, 2014-01, Vol.35 (1), p.109-110 |
| issn | 0971-5851 0975-2129 |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Thieme Connect Journals Open Access; PubMed Central |
| subjects | Adenocarcinoma Antibiotics CASE REPORT Case studies Complications and side effects Epidermal growth factor Gefitinib Lung cancer Metastasis Mutation Skin Ulcers |
| title | Gefitinib-induced skin ulceration in metastatic adenocarcinoma lung |
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