Chronic mTOR activation promotes cell survival in Merkel cell carcinoma

Abstract Merkel cell carcinoma (MCC) is an aggressive skin cancer with rising incidence. In this study, we demonstrate that mTOR activation and suppressed autophagy is common in MCCs. mTOR inhibition in two primary human MCC cell lines induces autophagy and cell death that is independent of caspase...

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Veröffentlicht in:	Cancer letters 2014-03, Vol.344 (2), p.272-281
Hauptverfasser:	Lin, Zhenyu, McDermott, Amelia, Shao, Lijian, Kannan, Aarthi, Morgan, Michael, Stack, Brendan C, Moreno, Mauricio, Davis, Daniel A, Cornelius, Lynn A, Gao, Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Chloromethyl Ketones - pharmacology Apoptosis Autophagy Carcinoma, Merkel Cell - drug therapy Carcinoma, Merkel Cell - enzymology Carcinoma, Merkel Cell - pathology Caspases - metabolism Cell death Cell growth Cell Line, Tumor Cell Survival - physiology Enzyme Activation Formaldehyde Hematology, Oncology and Palliative Medicine Humans Immune system Kinases Melanoma Merkel cell carcinoma Mortality mTOR inhibitor mTOR pathway Paraffin Embedding Pathogenesis Phagosomes - enzymology Phagosomes - metabolism Phosphorylation Protein Kinase Inhibitors - pharmacology Proteins Skin cancer Skin Neoplasms - drug therapy Skin Neoplasms - enzymology Skin Neoplasms - pathology Studies Tissue Fixation TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism Tumors Up-Regulation
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