Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth

Angiotensin II type 2 (AT2) receptor is abundantly expressed in vascular smooth muscle cells (VSMC) of the fetal vasculature during late gestation (embryonic day 15-20), during which the blood vessels undergo remodeling. To examine directly the influence of AT2 receptor expression in the development...

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Veröffentlicht in:	The Journal of clinical investigation 1999-01, Vol.103 (1), p.63-71
Hauptverfasser:	Akishita, M, Ito, M, Lehtonen, J Y, Daviet, L, Dzau, V J, Horiuchi, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - metabolism Animals Blood Vessels - growth & development Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell Division - drug effects Cells, Cultured Culture Media - pharmacology DNA - biosynthesis Female Flavonoids - pharmacology Gene Expression Regulation, Developmental - genetics Imidazoles - pharmacology Losartan - pharmacology Mice Mice, Knockout Muscle Development Muscle, Smooth, Vascular - growth & development Okadaic Acid - pharmacology Phosphoproteins - analysis Phosphorylation Protein Binding Pyridines - pharmacology Receptors, Angiotensin - genetics Receptors, Angiotensin - metabolism Vanadates - pharmacology
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