A genomic selection strategy to identify accessible and dimerization blocking targets in the 5′‐UTR of HIV‐1 RNA

Defining target sites for antisense oligonucleotides in highly structured RNA is a non‐trivial exercise that has received much attention. Here we describe a novel and simple method to generate a library composed of all 20mer oligoribonucleotides that are sense‐ and antisense to any given sequence or...

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