Mechanisms of functional promiscuity by HP1 proteins

Highlights • HP1 proteins play diverse roles in vivo. • Functional versatility can arise from small sequence differences between HP1 paralogs. • Functional versatility may arise from conformational flexibility of an HP1 protein.

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Bibliographische Detailangaben
Veröffentlicht in:	Trends in cell biology 2014-06, Vol.24 (6), p.377-386
Hauptverfasser:	Canzio, Daniele, Larson, Adam, Narlikar, Geeta J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals chromatin Chromosomal Proteins, Non-Histone - chemistry Chromosomal Proteins, Non-Histone - metabolism conformational flexibility Eukaryota - genetics Eukaryota - metabolism functional versatility HP1 Humans Nucleosomes - metabolism Pathology
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Beschreibung
Zusammenfassung:	Highlights • HP1 proteins play diverse roles in vivo. • Functional versatility can arise from small sequence differences between HP1 paralogs. • Functional versatility may arise from conformational flexibility of an HP1 protein.
ISSN:	0962-8924 1879-3088
DOI:	10.1016/j.tcb.2014.01.002