Fronto-temporal Anatomical Connectivity and Working-Relational Memory Performance Predict Everyday Functioning in Schizophrenia
Hippocampal (relational memory) and prefrontal cortex (PFC; working memory) impairments have been found in patients with schizophrenia (SP), possibly due to a dysfunctional connection between structures. Neuroanatomical studies that describe reduced fractional anisotropy (FA) in the uncinate fascicu...
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| Veröffentlicht in: | Psychophysiology 2012-08, Vol.49 (10), p.1340-1352 |
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| container_title | Psychophysiology |
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| creator | Hanlon, Faith M. Houck, Jon M. Klimaj, Stefan D. Caprihan, Arvind Mayer, Andrew R. Weisend, Michael P. Bustillo, Juan R. Hamilton, Derek A. Tesche, Claudia D. |
| description | Hippocampal (relational memory) and prefrontal cortex (PFC; working memory) impairments have been found in patients with schizophrenia (SP), possibly due to a dysfunctional connection between structures. Neuroanatomical studies that describe reduced fractional anisotropy (FA) in the uncinate fasciculus support this idea. The dysconnection hypothesis in SP was investigated by examining fronto-temporal anatomical connectivity (uncinate fasciculus FA) and PFC-hippocampal memory and their relationship with each other and everyday functioning. PFC-hippocampal memory was examined with two working-relational memory tasks: transverse patterning and virtual Morris water task. SP exhibited a performance deficit on both tasks and had lower FA in bilateral uncinate fasciculus than healthy volunteers. Lower fronto-temporal anatomical connectivity was related to lower working-relational memory performance, and both predicted worse everyday functioning. |
| doi_str_mv | 10.1111/j.1469-8986.2012.01448.x |
| format | Article |
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Neuroanatomical studies that describe reduced fractional anisotropy (FA) in the uncinate fasciculus support this idea. The dysconnection hypothesis in SP was investigated by examining fronto-temporal anatomical connectivity (uncinate fasciculus FA) and PFC-hippocampal memory and their relationship with each other and everyday functioning. PFC-hippocampal memory was examined with two working-relational memory tasks: transverse patterning and virtual Morris water task. SP exhibited a performance deficit on both tasks and had lower FA in bilateral uncinate fasciculus than healthy volunteers. 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| title | Fronto-temporal Anatomical Connectivity and Working-Relational Memory Performance Predict Everyday Functioning in Schizophrenia |
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