An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E-/- mice

Oxidized low-density lipoprotein (oxLDL) inhibits mammalian target of rapamycin (mTOR) and induces autophagy and apoptosis in vascular endothelial cells (VECs) that play very critical roles for the cardiovascular homostasis. We recently defined 3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)...

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Veröffentlicht in:	Scientific reports 2014-07, Vol.4 (1), p.5519, Article 5519
Hauptverfasser:	Peng, Nan, Meng, Ning, Wang, ShengQing, Zhao, Fei, Zhao, Jing, Su, Le, Zhang, ShangLi, Zhang, Yun, Zhao, BaoXiang, Miao, JunYing
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 14/19 4-Butyrolactone - administration & dosage 4-Butyrolactone - analogs & derivatives 631/443/592/2100 631/443/592/75/593 82/80 Animals Apolipoprotein E Apolipoproteins Apolipoproteins E - genetics Apolipoproteins E - metabolism Apoptosis Arteriosclerosis Atherosclerosis Atherosclerosis - metabolism Atherosclerosis - prevention & control Autophagy Cell death Dephosphorylation Dose-Response Relationship, Drug Endothelial cells Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelium Humanities and Social Sciences Lesions Lipoproteins, LDL - administration & dosage Low density lipoprotein Macrophages Male Mice Mice, Inbred C57BL Mice, Knockout multidisciplinary Phagocytosis Rapamycin Science Smooth muscle TOR protein TOR Serine-Threonine Kinases - metabolism Treatment Outcome Umbilical vein
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