mRNA stability in the nucleus
Eukaryotic gene expression is controlled by different levels of biological events, such as transcription factors regulating the timing and strength of transcripts production, alteration of transcription rate by RNA processing, and mRNA stability during RNA processing and translation. RNAs, especiall...
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| Veröffentlicht in: | Journal of Zhejiang University. B. Science 2014-05, Vol.15 (5), p.444-454 |
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| creator | Liu, Han Luo, Min Wen, Ji-kai |
| description | Eukaryotic gene expression is controlled by different levels of biological events, such as transcription factors regulating the timing and strength of transcripts production, alteration of transcription rate by RNA processing, and mRNA stability during RNA processing and translation. RNAs, especially mRNAs, are relatively vulnerable molecules in living cells for ribonucleases (RNases). The maintenance of quality and quantity of transcripts is a key issue for many biological processes. Extensive studies draw the conclusion that the stability of RNAs is dedicated-regulated, occurring co- and post-transcriptionally, and translation-coupled as well, either in the nucleus or cytoplasm. Recently, RNA stability in the nucleus has aroused much research interest, especially the stability of newly-made transcripts. In this article, we summarize recent progresses on mRNA stability in the nucleus, especially focusing on quality control of newly-made RNA by RNA polymerase II in eukaryotes. |
| doi_str_mv | 10.1631/jzus.B1400088 |
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RNAs, especially mRNAs, are relatively vulnerable molecules in living cells for ribonucleases (RNases). The maintenance of quality and quantity of transcripts is a key issue for many biological processes. Extensive studies draw the conclusion that the stability of RNAs is dedicated-regulated, occurring co- and post-transcriptionally, and translation-coupled as well, either in the nucleus or cytoplasm. Recently, RNA stability in the nucleus has aroused much research interest, especially the stability of newly-made transcripts. 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Science, 2014-05, Vol.15 (5), p.444-454</ispartof><rights>Zhejiang University and Springer-Verlag Berlin Heidelberg 2014</rights><rights>Copyright © Zhejiang University and Springer-Verlag Berlin Heidelberg 2014 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-79c8a585d2e7821894d4ee924adc989d041b18ca69c27d0f60838bbac80bd0513</citedby><cites>FETCH-LOGICAL-c487t-79c8a585d2e7821894d4ee924adc989d041b18ca69c27d0f60838bbac80bd0513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076601/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076601/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24793762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Han</creatorcontrib><creatorcontrib>Luo, Min</creatorcontrib><creatorcontrib>Wen, Ji-kai</creatorcontrib><title>mRNA stability in the nucleus</title><title>Journal of Zhejiang University. B. Science</title><addtitle>J. Zhejiang Univ. Sci. B</addtitle><addtitle>J Zhejiang Univ Sci B</addtitle><description>Eukaryotic gene expression is controlled by different levels of biological events, such as transcription factors regulating the timing and strength of transcripts production, alteration of transcription rate by RNA processing, and mRNA stability during RNA processing and translation. RNAs, especially mRNAs, are relatively vulnerable molecules in living cells for ribonucleases (RNases). The maintenance of quality and quantity of transcripts is a key issue for many biological processes. Extensive studies draw the conclusion that the stability of RNAs is dedicated-regulated, occurring co- and post-transcriptionally, and translation-coupled as well, either in the nucleus or cytoplasm. Recently, RNA stability in the nucleus has aroused much research interest, especially the stability of newly-made transcripts. In this article, we summarize recent progresses on mRNA stability in the nucleus, especially focusing on quality control of newly-made RNA by RNA polymerase II in eukaryotes.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Nucleus - physiology</subject><subject>DNA-Directed RNA Polymerases - genetics</subject><subject>Epigenesis, Genetic - genetics</subject><subject>Gene Expression Regulation - genetics</subject><subject>Genetics and Gene Regulation</subject><subject>Humans</subject><subject>Models, Genetic</subject><subject>Review</subject><subject>RNA Stability - genetics</subject><subject>RNA, Messenger - genetics</subject><subject>Transcription, Genetic - genetics</subject><subject>Transcriptional Activation - genetics</subject><issn>1673-1581</issn><issn>1862-1783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkctLw0AQxhdRrFaPHpWAFy-p-8ru5CLU4guKguh52Wy2bUoeNZsI9a93Qx9U8eBpBubHN_PNh9AZwQMiGLmef7VucEs4xhhgDx0REDQkEti-74VkIYmA9NCxc3OMOcdSHKIe5TJmUtAjdF68Pg8D1-gky7NmGWRl0MxsULYmt607QQcTnTt7uq599H5_9zZ6DMcvD0-j4Tg0HGQTytiAjiBKqZVACcQ85dbGlOvUxBCnmJOEgNEiNlSmeCIwMEgSbQAnKY4I66Oble6iTQqbGls2tc7Vos4KXS9VpTP1c1JmMzWtPlXnR-BO4GotUFcfrXWNKjJnbJ7r0latUyRikgCm_F8oB0a4lB69_IXOq7Yu_Sc8RZn_JxbUU-GKMnXlXG0n27sJVl1GqstIbTLy_MWu2S29CcUDgxXg_Kic2npn7Z-K30Qtmlc</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Liu, Han</creator><creator>Luo, Min</creator><creator>Wen, Ji-kai</creator><general>Zhejiang University Press</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7QP</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7S</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>7TM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140501</creationdate><title>mRNA stability in the nucleus</title><author>Liu, Han ; 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| source | MEDLINE; Springer Online Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Biomedical and Life Sciences Biomedicine Cell Nucleus - physiology DNA-Directed RNA Polymerases - genetics Epigenesis, Genetic - genetics Gene Expression Regulation - genetics Genetics and Gene Regulation Humans Models, Genetic Review RNA Stability - genetics RNA, Messenger - genetics Transcription, Genetic - genetics Transcriptional Activation - genetics |
| title | mRNA stability in the nucleus |
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