DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation

Mast cells play a key role in the induction of anaphylaxis, a life-threatening IgE-dependent allergic reaction, by secreting chemical mediators that are stored in secretory granules. Degranulation of mast cells is triggered by aggregation of the high-affinity IgE receptor, FcεRI, and involves dynami...

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Veröffentlicht in:	The Journal of experimental medicine 2014-06, Vol.211 (7), p.1407-1419
Hauptverfasser:	Ogawa, Kana, Tanaka, Yoshihiko, Uruno, Takehito, Duan, Xuefeng, Harada, Yosuke, Sanematsu, Fumiyuki, Yamamura, Kazuhiko, Terasawa, Masao, Nishikimi, Akihiko, Côté, Jean-François, Fukui, Yoshinori
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - immunology Animals Cell Degranulation - genetics Cell Degranulation - immunology Cells, Cultured Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - immunology Mast Cells - cytology Mast Cells - immunology Mice Mice, Knockout Microtubules - genetics Microtubules - immunology Oncogene Proteins - genetics Oncogene Proteins - immunology Phosphorylation - genetics Phosphorylation - immunology Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - immunology Receptors, IgE - genetics Receptors, IgE - immunology Signal Transduction - genetics Signal Transduction - immunology
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