Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

Ever since eukaryotes subsumed the bacterial ancestor of mitochondria, the nuclear and mitochondrial genomes have had to closely coordinate their activities, as each encode different subunits of the oxidative phosphorylation (OXPHOS) system. Mitochondrial dysfunction is a hallmark of aging, but its...

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Veröffentlicht in:	Cell 2013-12, Vol.155 (7), p.1624-1638
Hauptverfasser:	Gomes, Ana P., Price, Nathan L., Ling, Alvin J.Y., Moslehi, Javid J., Montgomery, Magdalene K., Rajman, Luis, White, James P., Teodoro, João S., Wrann, Christiane D., Hubbard, Basil P., Mercken, Evi M., Palmeira, Carlos M., de Cabo, Rafael, Rolo, Anabela P., Turner, Nigel, Bell, Eric L., Sinclair, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - pathology AMP-Activated Protein Kinases - metabolism Animals Cell Nucleus - metabolism eukaryotic cells hypoxia-inducible factor 1 Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Mice mitochondria Mitochondria - metabolism mitochondrial genome Muscle, Skeletal - metabolism NAD - metabolism normoxia Oxidative Phosphorylation Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Reactive Oxygen Species - metabolism Sirtuin 1 - metabolism Transcription Factors - metabolism
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