Early Endosomal Escape of a Cyclic Cell-Penetrating Peptide Allows Effective Cytosolic Cargo Delivery

Cyclic heptapeptide cyclo­(FΦRRRRQ) (cFΦR4, where Φ is l-2-naphthylalanine) was recently found to be efficiently internalized by mammalian cells. In this study, its mechanism of internalization was investigated by perturbing various endocytic events through the introduction of pharmacologic agents a...

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Veröffentlicht in:	Biochemistry (Easton) 2014-06, Vol.53 (24), p.4034-4046
Hauptverfasser:	Qian, Ziqing, LaRochelle, Jonathan R, Jiang, Bisheng, Lian, Wenlong, Hard, Ryan L, Selner, Nicholas G, Luechapanichkul, Rinrada, Barrios, Amy M, Pei, Dehua
Format:	Artikel
Sprache:	eng
Schlagworte:	Carrier Proteins - metabolism Cell-Penetrating Peptides - metabolism Cytoplasm - metabolism Cytosol - metabolism Drug Delivery Systems - methods Endosomes - metabolism Gene Products, tat - metabolism HeLa Cells Humans Microscopy, Confocal Oligopeptides - metabolism Peptides, Cyclic - metabolism Transport Vesicles - metabolism
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