Immobilized Lentivirus Vector on Chondroitin Sulfate-Hyaluronate Acid-Silk Fibroin Hybrid Scaffold for Tissue-Engineered Ligament-Bone Junction

The lack of a fibrocartilage layer between graft and bone remains the leading cause of graft failure after anterior cruciate ligament (ACL) reconstruction. The objective of this study was to develop a gene-modified silk cable-reinforced chondroitin sulfate-hyaluronate acid-silk fibroin (CHS) hybrid...

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Veröffentlicht in:	BioMed research international 2014-01, Vol.2014 (2014), p.1-10
Hauptverfasser:	Sun, Liguo, Li, Hongguo, Qu, Ling, Zhu, Rui, Fan, Xiangli, Xue, Yingsen, Xie, Zhenghong, Fan, Hongbin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Animals Biocompatible Materials - chemical synthesis Biomechanics Bone and Bones - cytology Bone and Bones - physiology Bone surgery Cables Cell Adhesion - physiology Cell Differentiation - physiology Cell growth Cell Proliferation - physiology Cells, Cultured Chondroitin sulfate Chondroitin Sulfates - chemistry Collagen Collagens Culture Differentiation Fibroins - chemistry Genes Genetic Vectors - genetics Grafting Health aspects Hospitals Hyaluronic Acid - chemistry Lentivirus Lentivirus - genetics Ligaments Ligaments - cytology Ligaments - physiology Materials Testing Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - physiology Orthopedic surgery Rabbits Scaffolds Silk Tensile strength Tissue engineering Tissue Engineering - instrumentation Tissue Engineering - methods Tissue Scaffolds Transforming Growth Factor beta3 - genetics
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