The Role of the Selective Adaptor p62 and Ubiquitin-Like Proteins in Autophagy
The ubiquitin-proteasome system and autophagy were long viewed as independent, parallel degradation systems with no point of intersection. By now we know that these degradation pathways share certain substrates and regulatory molecules and show coordinated and compensatory function. Two ubiquitin-li...
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| Veröffentlicht in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-11 |
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| description | The ubiquitin-proteasome system and autophagy were long viewed as independent, parallel degradation systems with no point of intersection. By now we know that these degradation pathways share certain substrates and regulatory molecules and show coordinated and compensatory function. Two ubiquitin-like protein conjugation pathways were discovered that are required for autophagosome biogenesis: the Atg12-Atg5-Atg16 and Atg8 systems. Autophagy has been considered to be essentially a nonselective process, but it turned out to be at least partially selective. Selective substrates of autophagy include damaged mitochondria, intracellular pathogens, and even a subset of cytosolic proteins with the help of ubiquitin-binding autophagic adaptors, such as p62/SQSTM1, NBR1, NDP52, and Optineurin. These proteins selectively recognize autophagic cargo and mediate its engulfment into autophagosomes by binding to the small ubiquitin-like modifiers that belong to the Atg8/LC3 family. |
| doi_str_mv | 10.1155/2014/832704 |
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These proteins selectively recognize autophagic cargo and mediate its engulfment into autophagosomes by binding to the small ubiquitin-like modifiers that belong to the Atg8/LC3 family.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/832704</identifier><identifier>PMID: 25013806</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Apoptosis ; Autophagy ; Autophagy (Cytology) ; Autophagy - genetics ; Cell cycle ; Cellular signal transduction ; Enzymes ; Humans ; Nuclear Proteins - metabolism ; Observations ; Oxidative stress ; Physiological aspects ; Protein Binding ; Proteins ; Proteins - metabolism ; Regulation ; Review ; RNA-Binding Proteins - genetics ; RNA-Binding Proteins - metabolism ; Signal transduction ; Stress response ; Transcription Factor TFIIIA - metabolism ; Ubiquitin - metabolism ; Ubiquitin-proteasome system ; Ubiquitins - genetics ; Ubiquitins - metabolism</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-11</ispartof><rights>Copyright © 2014 Mónika Lippai and Péter Lőw.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 Mónika Lippai and Péter Low. 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| subjects | Apoptosis Autophagy Autophagy (Cytology) Autophagy - genetics Cell cycle Cellular signal transduction Enzymes Humans Nuclear Proteins - metabolism Observations Oxidative stress Physiological aspects Protein Binding Proteins Proteins - metabolism Regulation Review RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Signal transduction Stress response Transcription Factor TFIIIA - metabolism Ubiquitin - metabolism Ubiquitin-proteasome system Ubiquitins - genetics Ubiquitins - metabolism |
| title | The Role of the Selective Adaptor p62 and Ubiquitin-Like Proteins in Autophagy |
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