Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome

Abstract Crohn's disease (CD) is a multifactorial pathology associated with the presence of adherent-invasive Escherichia coli (AIEC) and NLRP3 polymorphic variants. The presence of intracellular E. coli in other intestinal pathologies (OIP) and the role of NLRP3-inflammasome in the immune resp...

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Veröffentlicht in:	International journal of medical microbiology 2014-05, Vol.304 (3), p.384-392
Hauptverfasser:	De la Fuente, Marjorie, Franchi, Luigi, Araya, Daniela, Díaz-Jiménez, David, Olivares, Mauricio, Álvarez-Lobos, Manuel, Golenbock, Douglas, González, María-Julieta, López-Kostner, Francisco, Quera, Rodrigo, Núñez, Gabriel, Vidal, Roberto, Hermoso, Marcela A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Animals Bacterial Load Biopsy Carrier Proteins - metabolism Cell Line Crohn's disease Cytosol - microbiology E. coli Epithelial Cells - microbiology Escherichia coli Escherichia coli - genetics Escherichia coli - immunology Escherichia coli - isolation & purification Escherichia coli - physiology Female Genotype Host-Pathogen Interactions Humans IL-1β Ileum - microbiology Ileum - pathology Infectious Disease Inflammasome Inflammasomes - metabolism Inflammatory Bowel Diseases - microbiology Macrophages - microbiology Male Medical Education Mice Microbial Viability Middle Aged NLR Family, Pyrin Domain-Containing 3 Protein NLRP3 Virulence Factors - genetics Young Adult
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