A CULLINary ride across the secretory pathway: more than just secretion

Highlights • Particular cullin-RING ubiquitin ligases (CRLs) are localized to the secretory pathway. • At the ER, CRLs modify vesicle coat proteins and may aid large cargo export. • CRLs aid ER-associated destruction of misfolded proteins. • Unidentified CRL substrates regulate the maintenance of no...

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Veröffentlicht in:	Trends in cell biology 2014-07, Vol.24 (7), p.389-399
Hauptverfasser:	Lu, Albert, Pfeffer, Suzanne R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cullin proteins Cullin Proteins - metabolism cullin-RING ligases Endosomes - metabolism Endosomes - physiology Golgi Apparatus - metabolism Golgi Apparatus - physiology Golgi complex Humans Pathology post-translational modification Protein Transport - physiology Secretory Pathway - physiology Ubiquitin-Protein Ligases - metabolism Ubiquitination - physiology ubiquitylation
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Beschreibung
Zusammenfassung:	Highlights • Particular cullin-RING ubiquitin ligases (CRLs) are localized to the secretory pathway. • At the ER, CRLs modify vesicle coat proteins and may aid large cargo export. • CRLs aid ER-associated destruction of misfolded proteins. • Unidentified CRL substrates regulate the maintenance of normal Golgi structure. • CRLs may regulate secretory flux, cell cycle progression, and Wnt signaling.
ISSN:	0962-8924 1879-3088
DOI:	10.1016/j.tcb.2014.02.001