Rethinking Differentiation: Stem Cells, Regeneration, and Plasticity

Cell differentiation is an essential process for the development, growth, reproduction, and longevity of all multicellular organisms, and its regulation has been the focus of intense investigation for the past four decades. The study of natural and induced stem cells has ushered an age of re-examina...

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Veröffentlicht in:Cell 2014-03, Vol.157 (1), p.110-119
Hauptverfasser: Sánchez Alvarado, Alejandro, Yamanaka, Shinya
Format: Artikel
Sprache:eng
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Zusammenfassung:Cell differentiation is an essential process for the development, growth, reproduction, and longevity of all multicellular organisms, and its regulation has been the focus of intense investigation for the past four decades. The study of natural and induced stem cells has ushered an age of re-examination of what it means to be a stem or a differentiated cell. Past and recent discoveries in plants and animals, as well as novel experimental manipulations, are beginning to erode many of these established concepts and are forcing a re-evaluation of the experimental systems and paradigms presently being used to explore these and other biological process.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2014.02.041