Risk of HIV acquisition among circumcised and uncircumcised young men with penile human papillomavirus infection
There are very few data from men on the risk of HIV acquisition associated with penile human papillomavirus (HPV) infection and no data on the potential modifying effect of male circumcision. Therefore, this study evaluated whether HPV is independently associated with risk of HIV. A cohort study of...
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| Veröffentlicht in: | AIDS (London) 2014-03, Vol.28 (5), p.745-752 |
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| creator | ROSITCH, Anne F LU MAO SMITH, Jennifer S HUDGENS, Michael G MOSES, Stephen AGOT, Kawango BACKES, Danielle M NYAGAYA, Edith SNIJDERS, Peter J. F MEIJER, Chris J. L. M BAILEY, Robert C |
| description | There are very few data from men on the risk of HIV acquisition associated with penile human papillomavirus (HPV) infection and no data on the potential modifying effect of male circumcision. Therefore, this study evaluated whether HPV is independently associated with risk of HIV.
A cohort study of HPV natural history nested within a randomized control trial of male circumcision to reduce HIV incidence in Kisumu, Kenya.
Prospective data from 2519 men were analyzed using 6-month discrete-time Cox models to determine if HIV acquisition was higher among circumcised or uncircumcised men with HPV compared to HPV-uninfected men.
Risk of HIV acquisition was nonsignificantly increased among men with any HPV [adjusted hazard ratio (aHR) 1.72; 95% confidence interval (CI) 0.94-3.15] and high-risk HPV (aHR 1.92; 95% CI 0.96-3.87) compared to HPV-uninfected men, and estimates did not differ by circumcision status. Risk of HIV increased 27% with each additional HPV genotype infection (aHR 1.27; 95% CI 1.09-1.48). Men with persistent (aHR 3.27; 95% CI 1.59-6.72) or recently cleared (aHR 3.05; 95% CI 1.34-6.97) HPV had a higher risk of HIV acquisition than HPV-uninfected men.
Consistent with the findings in women, HPV infection, clearance, and persistence were associated with an increased risk of HIV acquisition in men. Given the high prevalence of HPV in populations at risk of HIV, consideration of HPV in future HIV-prevention studies and investigation into mechanisms through which HPV might facilitate HIV acquisition are needed. |
| doi_str_mv | 10.1097/QAD.0000000000000092 |
| format | Article |
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A cohort study of HPV natural history nested within a randomized control trial of male circumcision to reduce HIV incidence in Kisumu, Kenya.
Prospective data from 2519 men were analyzed using 6-month discrete-time Cox models to determine if HIV acquisition was higher among circumcised or uncircumcised men with HPV compared to HPV-uninfected men.
Risk of HIV acquisition was nonsignificantly increased among men with any HPV [adjusted hazard ratio (aHR) 1.72; 95% confidence interval (CI) 0.94-3.15] and high-risk HPV (aHR 1.92; 95% CI 0.96-3.87) compared to HPV-uninfected men, and estimates did not differ by circumcision status. Risk of HIV increased 27% with each additional HPV genotype infection (aHR 1.27; 95% CI 1.09-1.48). Men with persistent (aHR 3.27; 95% CI 1.59-6.72) or recently cleared (aHR 3.05; 95% CI 1.34-6.97) HPV had a higher risk of HIV acquisition than HPV-uninfected men.
Consistent with the findings in women, HPV infection, clearance, and persistence were associated with an increased risk of HIV acquisition in men. Given the high prevalence of HPV in populations at risk of HIV, consideration of HPV in future HIV-prevention studies and investigation into mechanisms through which HPV might facilitate HIV acquisition are needed.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/QAD.0000000000000092</identifier><identifier>PMID: 24149088</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Biological and medical sciences ; Circumcision, Male ; Cohort Studies ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; HIV Infections - epidemiology ; HIV Infections - transmission ; Human papillomavirus ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Incidence ; Infectious diseases ; Kenya ; Lentivirus ; Male ; Medical sciences ; Papillomaviridae ; Papillomavirus Infections - complications ; Penile Diseases - complications ; Prospective Studies ; Retroviridae ; Risk Assessment ; Treatment Outcome ; Tumors ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Young Adult</subject><ispartof>AIDS (London), 2014-03, Vol.28 (5), p.745-752</ispartof><rights>2015 INIST-CNRS</rights><rights>2014 Wolters Kluwer Health | Lippincott Williams & Wilkins 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-163ad7c61d064bf7946e48c6457ff9731613ddfe2f8781ce82995633dc97e3e93</citedby><cites>FETCH-LOGICAL-c471t-163ad7c61d064bf7946e48c6457ff9731613ddfe2f8781ce82995633dc97e3e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,778,782,883,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28403021$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24149088$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ROSITCH, Anne F</creatorcontrib><creatorcontrib>LU MAO</creatorcontrib><creatorcontrib>SMITH, Jennifer S</creatorcontrib><creatorcontrib>HUDGENS, Michael G</creatorcontrib><creatorcontrib>MOSES, Stephen</creatorcontrib><creatorcontrib>AGOT, Kawango</creatorcontrib><creatorcontrib>BACKES, Danielle M</creatorcontrib><creatorcontrib>NYAGAYA, Edith</creatorcontrib><creatorcontrib>SNIJDERS, Peter J. F</creatorcontrib><creatorcontrib>MEIJER, Chris J. L. M</creatorcontrib><creatorcontrib>BAILEY, Robert C</creatorcontrib><title>Risk of HIV acquisition among circumcised and uncircumcised young men with penile human papillomavirus infection</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>There are very few data from men on the risk of HIV acquisition associated with penile human papillomavirus (HPV) infection and no data on the potential modifying effect of male circumcision. Therefore, this study evaluated whether HPV is independently associated with risk of HIV.
A cohort study of HPV natural history nested within a randomized control trial of male circumcision to reduce HIV incidence in Kisumu, Kenya.
Prospective data from 2519 men were analyzed using 6-month discrete-time Cox models to determine if HIV acquisition was higher among circumcised or uncircumcised men with HPV compared to HPV-uninfected men.
Risk of HIV acquisition was nonsignificantly increased among men with any HPV [adjusted hazard ratio (aHR) 1.72; 95% confidence interval (CI) 0.94-3.15] and high-risk HPV (aHR 1.92; 95% CI 0.96-3.87) compared to HPV-uninfected men, and estimates did not differ by circumcision status. Risk of HIV increased 27% with each additional HPV genotype infection (aHR 1.27; 95% CI 1.09-1.48). Men with persistent (aHR 3.27; 95% CI 1.59-6.72) or recently cleared (aHR 3.05; 95% CI 1.34-6.97) HPV had a higher risk of HIV acquisition than HPV-uninfected men.
Consistent with the findings in women, HPV infection, clearance, and persistence were associated with an increased risk of HIV acquisition in men. Given the high prevalence of HPV in populations at risk of HIV, consideration of HPV in future HIV-prevention studies and investigation into mechanisms through which HPV might facilitate HIV acquisition are needed.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Circumcision, Male</subject><subject>Cohort Studies</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Infections - transmission</subject><subject>Human papillomavirus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Incidence</subject><subject>Infectious diseases</subject><subject>Kenya</subject><subject>Lentivirus</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Papillomaviridae</subject><subject>Papillomavirus Infections - complications</subject><subject>Penile Diseases - complications</subject><subject>Prospective Studies</subject><subject>Retroviridae</subject><subject>Risk Assessment</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Young Adult</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFTEUhoMo9lr9ByLZCG6m5vtjI5RWbaEgiroNaSbpjc4k02RS6b83pdfaujGbE3Ke83LCA8BLjA4w0vLt58PjA_TgaPIIbDCTdOBc4sdgg4jQg6YS7YFntf7oCEdKPQV7hGGm-3UDli-x_oQ5wJPT79C6yxZrXGNO0M45XUAXi2uzi9WP0KYRtnT_5Tq3zsw-wV9x3cLFpzh5uG2zTXCxS5ymPNurWFqFMQXvboKfgyfBTtW_2NV98O3D-69HJ8PZp4-nR4dng2MSrwMW1I7SCTwiwc6D1Ex4ppxgXIagJcUC03EMngQlFXZeEa25oHR0WnrqNd0H725zl3Y--9H5tBY7maXE2ZZrk200Dzspbs1FvjIMSUY46gFvdgElXzZfVzPH6vw02eRzqwZLwbXQSun_o5wRwQlVsqPsFnUl11p8uNsII3Pj1XSv5l-vfezV_d_cDf0R2YHXO8BWZ6dQbDdV_3KKIYoIpr8BiIms7A</recordid><startdate>20140313</startdate><enddate>20140313</enddate><creator>ROSITCH, Anne F</creator><creator>LU MAO</creator><creator>SMITH, Jennifer S</creator><creator>HUDGENS, Michael G</creator><creator>MOSES, Stephen</creator><creator>AGOT, Kawango</creator><creator>BACKES, Danielle M</creator><creator>NYAGAYA, Edith</creator><creator>SNIJDERS, Peter J. F</creator><creator>MEIJER, Chris J. L. M</creator><creator>BAILEY, Robert C</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7T5</scope><scope>7U2</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20140313</creationdate><title>Risk of HIV acquisition among circumcised and uncircumcised young men with penile human papillomavirus infection</title><author>ROSITCH, Anne F ; LU MAO ; SMITH, Jennifer S ; HUDGENS, Michael G ; MOSES, Stephen ; AGOT, Kawango ; BACKES, Danielle M ; NYAGAYA, Edith ; SNIJDERS, Peter J. F ; MEIJER, Chris J. L. M ; BAILEY, Robert C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-163ad7c61d064bf7946e48c6457ff9731613ddfe2f8781ce82995633dc97e3e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Circumcision, Male</topic><topic>Cohort Studies</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>HIV Infections - epidemiology</topic><topic>HIV Infections - transmission</topic><topic>Human papillomavirus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Incidence</topic><topic>Infectious diseases</topic><topic>Kenya</topic><topic>Lentivirus</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Papillomaviridae</topic><topic>Papillomavirus Infections - complications</topic><topic>Penile Diseases - complications</topic><topic>Prospective Studies</topic><topic>Retroviridae</topic><topic>Risk Assessment</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ROSITCH, Anne F</creatorcontrib><creatorcontrib>LU MAO</creatorcontrib><creatorcontrib>SMITH, Jennifer S</creatorcontrib><creatorcontrib>HUDGENS, Michael G</creatorcontrib><creatorcontrib>MOSES, Stephen</creatorcontrib><creatorcontrib>AGOT, Kawango</creatorcontrib><creatorcontrib>BACKES, Danielle M</creatorcontrib><creatorcontrib>NYAGAYA, Edith</creatorcontrib><creatorcontrib>SNIJDERS, Peter J. F</creatorcontrib><creatorcontrib>MEIJER, Chris J. L. M</creatorcontrib><creatorcontrib>BAILEY, Robert C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Safety Science and Risk</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ROSITCH, Anne F</au><au>LU MAO</au><au>SMITH, Jennifer S</au><au>HUDGENS, Michael G</au><au>MOSES, Stephen</au><au>AGOT, Kawango</au><au>BACKES, Danielle M</au><au>NYAGAYA, Edith</au><au>SNIJDERS, Peter J. F</au><au>MEIJER, Chris J. L. M</au><au>BAILEY, Robert C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of HIV acquisition among circumcised and uncircumcised young men with penile human papillomavirus infection</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>2014-03-13</date><risdate>2014</risdate><volume>28</volume><issue>5</issue><spage>745</spage><epage>752</epage><pages>745-752</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>There are very few data from men on the risk of HIV acquisition associated with penile human papillomavirus (HPV) infection and no data on the potential modifying effect of male circumcision. Therefore, this study evaluated whether HPV is independently associated with risk of HIV.
A cohort study of HPV natural history nested within a randomized control trial of male circumcision to reduce HIV incidence in Kisumu, Kenya.
Prospective data from 2519 men were analyzed using 6-month discrete-time Cox models to determine if HIV acquisition was higher among circumcised or uncircumcised men with HPV compared to HPV-uninfected men.
Risk of HIV acquisition was nonsignificantly increased among men with any HPV [adjusted hazard ratio (aHR) 1.72; 95% confidence interval (CI) 0.94-3.15] and high-risk HPV (aHR 1.92; 95% CI 0.96-3.87) compared to HPV-uninfected men, and estimates did not differ by circumcision status. Risk of HIV increased 27% with each additional HPV genotype infection (aHR 1.27; 95% CI 1.09-1.48). Men with persistent (aHR 3.27; 95% CI 1.59-6.72) or recently cleared (aHR 3.05; 95% CI 1.34-6.97) HPV had a higher risk of HIV acquisition than HPV-uninfected men.
Consistent with the findings in women, HPV infection, clearance, and persistence were associated with an increased risk of HIV acquisition in men. Given the high prevalence of HPV in populations at risk of HIV, consideration of HPV in future HIV-prevention studies and investigation into mechanisms through which HPV might facilitate HIV acquisition are needed.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>24149088</pmid><doi>10.1097/QAD.0000000000000092</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | AIDS (London), 2014-03, Vol.28 (5), p.745-752 |
| issn | 0269-9370 1473-5571 |
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| source | MEDLINE; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Biological and medical sciences Circumcision, Male Cohort Studies Female genital diseases Gynecology. Andrology. Obstetrics HIV Infections - epidemiology HIV Infections - transmission Human papillomavirus Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Incidence Infectious diseases Kenya Lentivirus Male Medical sciences Papillomaviridae Papillomavirus Infections - complications Penile Diseases - complications Prospective Studies Retroviridae Risk Assessment Treatment Outcome Tumors Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Young Adult |
| title | Risk of HIV acquisition among circumcised and uncircumcised young men with penile human papillomavirus infection |
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